Evidence map›Paper›PMID 26951452›Full record

ArticleMolecular neurobiology2017

Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions.

Jen-Hui Tsou, Ying-Chen Yang, Ping-Chieh Pao, Hui-Ching Lin, Nai-Kuei Huang, Shih-Ting Lin, Kuei-Sen Hsu, Che-Ming Yeh, Kuen-Haur Lee, Chu-Jen Kuo and 4 more

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Structural and functional characterization of the brain-specific dynamin superfamily member RNF112.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Risk of Alzheimer's disease in Down syndrome: Insights gained by multi-omics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Jen-Hui TsouGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ying-Chen YangDepartment of Biotechnology and Animal Science, College of Bioresources, National Ilan University, Ilan, Taiwan.
Ping-Chieh PaoGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Hui-Ching LinDepartment and Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Nai-Kuei HuangNational Research Institute of Chinese Medicine, Taipei, Taiwan.
Shih-Ting LinDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kuei-Sen HsuDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Che-Ming YehInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kuen-Haur LeeGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Chu-Jen KuoPh.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan.
De-Ming YangDepartment of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan.
Jiann-Her LinPh.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan.
Wen-Chang ChangGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yi-Chao LeePh.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan. yclee@tmu.edu.tw.ORCID 0000-0003-3451-183X
Taipei Medical University · TWNational Cheng Kung University · TWNational Yang Ming Chiao Tung University · TWFu Jen Catholic University · TWNational Ilan University · TWNational Research Institute of Chinese Medicine · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rnf112 is a member of the RING finger protein family. The expression of Rnf112 is abundant in the brain and is regulated during brain development. Our previous study has revealed that Rnf112 can promote neuronal differentiation by inhibiting the progression of the cell cycle in cell models. In this study, we further revealed the important functions of Rnf112 in embryo development and in adult brain. Our data showed that most of the Rnf112

Indexed as

AnimalsBehavior, AnimalBrainDNA-Binding ProteinsImaging, Three-DimensionalLearningMemoryMiceMice, Inbred C57BLMice, KnockoutDNA-Binding ProteinsZNF179 protein, mouseBrain finger proteinGrowth retardationMemory impairmentRnf112Znf179

Identifiers

PMID26951452
OpenAlexW2295636305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.