ArticleIntensive care medicine2016
Early goal-directed therapy: do we have a definitive answer?
Article in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review.Critical care (London, England) · 2023Pooled it
- Impact of red blood cell transfusion on oxygen transport and metabolism in patients with sepsis and septic shock: a systematic review and meta-analysis.Revista Brasileira de terapia intensivaPooled it
- Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study.Critical care medicine · 2017Trial
- A plea for personalization of the hemodynamic management of septic shock.Critical care (London, England) · 2022Review
- Through the Looking Glass: The Paradoxical Evolution of Targeted Temperature Management for Comatose Survivors of Cardiac Arrest.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Toward a Better Mechanistic Understanding of Critical Illness: Endothelial, Microvascular and Coagulation Dysfunction.Critical care clinics · 2020Article
- Automated systems for perioperative goal-directed hemodynamic therapy.Journal of anesthesia · 2020Review
- How I treat septic shock.Intensive care medicine · 2018Article
- Do trials that report a neutral or negative treatment effect improve the care of critically ill patients? No.Intensive care medicine · 2018Article
- Is early goal-directed therapy associated with a higher risk of adverse events?Journal of intensive care · 2018Article
- Detailing the cardiovascular profile in shock patients.Critical care (London, England) · 2017Review
- Correlation of central venous pressure with venous blood gas analysis parameters; a diagnostic study.Turkish journal of emergency medicine · 2017Article
- Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy.Intensive care medicine · 2016Review
- Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No.Intensive care medicine · 2016Article
- Advanced Hemodynamic Management in Patients with Septic Shock.BioMed research international · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
26951428What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.