Evidence map›Paper›PMID 26951420›Full record

Observational studyJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2016

The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.

Bernardo J Selim, Brian B Koo, Li Qin, Sangchoon Jeon, Christine Won, Nancy S Redeker, Rachel J Lampert, John P Concato, Dawn M Bravata, Jared Ferguson and 4 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Sleep-Disordered Breathing and Cardiac Arrhythmias.Journal of clinical medicine · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Obstructive Sleep Apnea and Atrial Fibrillation.Journal of clinical medicine · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Bernardo J SelimSection of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
Brian B KooDepartment of Neurology, Connecticut Veterans Affairs Health System, West Haven, CT.
Li QinYale Center of Analytical Science (YCAS) Yale School of Epidemiology and Public Health, New Haven, CT.
Sangchoon JeonDivision of Acute Care/Health Systems, Yale School of Nursing, New Haven, CT.
Christine WonDepartment of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine Yale University School of Medicine, New Haven, CT.
Nancy S RedekerDivision of Acute Care/Health Systems, Yale School of Nursing, New Haven, CT.
Rachel J LampertDepartment of Internal Medicine, Section of Cardiology/Electrophysiology, Yale University School of Medicine, New Haven, CT.
John P ConcatoDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT.
Dawn M BravataDepartments of Internal Medicine, Indiana University School of Medicine and the Regenstrief Institute, Indianapolis, IN.
Jared FergusonDepartments of Internal Medicine, Indiana University School of Medicine and the Regenstrief Institute, Indianapolis, IN.
Kingman StrohlDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH.
Adam BennettDepartment of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine Yale University School of Medicine, New Haven, CT.
Andrey ZinchukDepartment of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine Yale University School of Medicine, New Haven, CT.
Henry K YaggiDepartment of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine Yale University School of Medicine, New Haven, CT.
Yale University · USRegenstrief Institute · USYale New Haven Health System · USMayo Clinic in Florida · USUniversity School · US

Funding

Yale Center for Sleep Disturbance in Acute and Chronic ConditionsP20NR014126 · NINR · YALE UNIVERSITY · PI KRYGER, MEIR H, YAGGI, HENRY KLAR · 2012 to 2016
$1.4M
Mentoring in Sleep Research and Sleep Interventions in Heart Disease, and StrokeK24HL132093 · NHLBI · YALE UNIVERSITY · PI YAGGI, HENRY KLAR · 2016 to 2020
$336k
NHLBI NIH HHS K24 HL132093NINR NIH HHS P20 NR014126
6 · The paper itself

Abstract

STUDY

objectivesTo determine whether sleep-disordered breathing (SDB) is associated with cardiac arrhythmia in a clinic-based population with multiple cardiovascular comorbidities and severe SDB.

methodsThis was a cross-sectional analysis of 697 veterans who underwent polysomnography for suspected SDB. SDB was categorized according to the apnea-hypopnea index (AHI): none (AHI < 5), mild (5 ≥ AHI < 15), and moderate-severe (AHI ≥ 15). Nocturnal cardiac arrhythmias consisted of: (1) complex ventricular ectopy, (CVE: non-sustained ventricular tachycardia, bigeminy, trigeminy, or quadrigeminy), (2) combined supraventricular tachycardia, (CST: atrial fibrillation or supraventricular tachycardia), (3) intraventricular conduction delay (ICD), (4) tachyarrhythmias (ventricular and supraventricular), and (5) any cardiac arrhythmia. Unadjusted, adjusted logistic regression, and Cochran-Armitage testing examined the association between SDB and cardiac arrhythmias. Linear regression models explored the association between hypoxia, arousals, and cardiac arrhythmias.

resultsCompared to those without SDB, patients with moderate-severe SDB had almost three-fold unadjusted odds of any cardiac arrhythmia (2.94; CI 95%, 2.01-4.30; p < 0.0001), two-fold odds of tachyarrhythmias (2.16; CI 95%,1.47-3.18; p = 0.0011), two-fold odds of CVE (2.01; 1.36-2.96; p = 0.003), and two-fold odds of ICD (2.50; 1.58-3.95; p = 0.001). A linear trend was identified between SDB severity and all cardiac arrhythmia subtypes (p value linear trend < 0.0001). After adjusting for age, BMI, gender, and cardiovascular diseases, moderate-severe SDB patients had twice the odds of having nocturnal cardiac arrhythmias (2.24; 1.48-3.39; p = 0.004). Frequency of obstructive respiratory events and hypoxia were strong predictors of arrhythmia risk.

conclusionsSDB is independently associated with nocturnal cardiac arrhythmias. Increasing severity of SDB was associated with an increasing risk for any cardiac arrhythmia.

Indexed as

Arrhythmias, CardiacCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedPolysomnographyProspective StudiesSeverity of Illness IndexSleep Apnea SyndromesVeteransatrial fibrillationautonomic nervous systemcardiac arrhythmiashypoxemiaobstructive sleep apneasleep-disordered breathingsudden cardiac death

Identifiers

PMID26951420
PMCPMC4877315
OpenAlexW2413362006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.