ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2016
Not Only Sleepwalking But NREM Parasomnia Irrespective of the Type Is Associated with HLA DQB1*05:01.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 78 citations in OpenAlex.
- Transdiagnostic cognitive behavioral therapy for nightmares and parasomnias.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
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- Sleep and Athletic Performance: A Multidimensional Review of Physiological and Molecular Mechanisms.Journal of clinical medicine · 2025Review
- Fever-induced acute sleep terrors in children and adolescents following SARS-CoV-2 infection.Sleep & breathing = Schlaf & Atmung · 2024Article
- HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease.Brain : a journal of neurology · 2024Article
- Fearful arousals in sleep terrors and sleep-related hypermotor epileptic seizures may involve the salience network and the acute stress response of Cannon and Selye.Epilepsy & behavior reports · 2024Review
- NREM Sleep Parasomnias Commencing in Childhood: Trauma and Atopy as Perpetuating Factors.Clocks & sleep · 2022Article
- What respiratory physicians should know about parasomnias.Breathe (Sheffield, England) · 2022Review
- Disorders of arousal and sleep-related hypermotor epilepsy - overview and challenges night is a battlefield of sleep and arousal promoting forces.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Sleep medicine: Practice, challenges and new frontiers.Frontiers in neurology · 2022Review
- Genetic and demographic predisposing factors associated with pediatric sleepwalking in the Philadelphia Neurodevelopmental Cohort.Journal of the neurological sciences · 2021Article
- The Genetics of Sleep Disorders in Children: A Narrative Review.Brain sciences · 2021Review
- Disorders of Arousal: A Chronobiological Perspective.Clocks & sleep · 2021Review
- Autonomic Modulation During Baseline and Recovery Sleep in Adult Sleepwalkers.Frontiers in neurology · 2021Article
- Dream enactment behavior: review for the clinician.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Abnormal things happening during sleep: parasomnias.Zeitschrift fur Gerontologie und Geriatrie · 2020Review
- Sleep Terrors: An Updated Review.Current pediatric reviews · 2020Review
- Adult NREM Parasomnias: An Update.Clocks & sleep · 2019Review
- NREM parasomnias: a treatment approach based upon a retrospective case series of 512 patients.Sleep medicine · 2019Article
- Parasomnias: A Comprehensive Review.Cureus · 2018Review
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesDespite the high prevalence and clinical relevance of NREM parasomnias, data on supportive genetic markers are scarce, and mainly refer to sleepwalking only.
methodsWe retrospectively analyzed clinical, polysomnographic, and HLA findings of 74 adults (37 men) with NREM parasomnia gathered from four neurological sleep centers. Parasomniac events were classified according to ICSD-2 criteria. HLA DQB1 genotyping was compared to regional-matched reference allele-frequencies.
resultsFifty-six patients had more than 2 different parasomnia type: 11 sleepwalking, 4 sleep terrors, 3 confusional arousals only. Parasomniac events were documented during video-polysomnography (V-PSG) in 70% (49/70) of subjects (71.4% confusional arousals, 8.2% sleep terrors, 4.1% sleepwalking, 16.3% ≥ 2 NREM parasomnia types). Violent behavior during V-PSG occurred in 8.5% (6/71). NREM parasomnia onset was reported after the age of 30 years in 6.8% (5/74). The HLA DQB1*05:01 allele was present in 41% (29/71) compared to 24.2% in the regional-matched reference allele group (p < 0.05). This haplotype prevalence did not differ within the NREM parasomnia type. Epworth Sleepiness Score was 10 or higher in 28.6%.
conclusionsThis is a large polysomnography-based case series of patients with NREM parasomnia. In patients with suspected sleepwalking or sleep terrors, polysomnography is highly useful in detecting arousals from NREM sleep as a marker of NREM parasomnia. We confirmed previous findings by demonstrating a high prevalence of the HLA DQB1*05:01 genotype for different types of NREM parasomnias. Our findings therefore support a common genetic background, and corroborate the importance of video-polysomnography in the work-up of parasomnia.
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