ArticleBrain structure & function2017
AII amacrine cells: quantitative reconstruction and morphometric analysis of electrophysiologically identified cells in live rat retinal slices imaged with multi-photon excitation microscopy.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Activation of Dopamine D1 Receptors at the Axon Initial Segment-Like Process of Retinal AII Amacrine Cells Modulates Action Potential Firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Efficient in vivo labeling of endogenous proteins with SMART delineates retina cellular and synaptic organization.Nature communications · 2025Article
- Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut-lung axis.Open biology · 2025Review
- IK Channel Confers Fine-tuning of Rod Bipolar Cell Excitation and Synaptic Transmission in the Retina.Function (Oxford, England) · 2025Article
- Near-Infrared Emissive Super Penetrating Conjugated Polymer Dots for Intratumoral Imaging in 3D Tumor Spheroid Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Functional properties of GABAFrontiers in ophthalmology · 2023Article
- Digital reconstruction and quantitative morphometric analysis of bipolar cells in live rat retinal slices.The Journal of comparative neurology · 2022Article
- The mosaic of AII amacrine cell bodies in rat retina is indistinguishable from a random distribution.Visual neuroscience · 2022Article
- Dendritic Morphology of an Inhibitory Retinal Interneuron Enables Simultaneous Local and Global Synaptic Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABAThe European journal of neuroscience · 2022Article
- Dendro-somatic synaptic inputs to ganglion cells contradict receptive field and connectivity conventions in the mammalian retina.Current biology : CB · 2022Article
- Article
- Differential Contribution of Gap Junctions to the Membrane Properties of ON- and OFF-Bipolar Cells of the Rat Retina.Cellular and molecular neurobiology · 2021Article
- Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells.Science advances · 2020Article
- Capacitance measurement of dendritic exocytosis in an electrically coupled inhibitory retinal interneuron: an experimental and computational study.Physiological reports · 2019Article
- Connexin-36 distribution and layer-specific topography in the cat retina.Brain structure & function · 2019Article
- Extrasynaptic NMDA Receptors on Rod Pathway Amacrine Cells: Molecular Composition, Activation, and Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Functional Compartmentalization within Starburst Amacrine Cell Dendrites in the Retina.Cell reports · 2018Article
- Transcriptional regulation of ependymal cell maturation within the postnatal brain.Neural development · 2018Article
- Inner Plexiform Layer Substrata Are Discernible with Commercial OCT and Affected by Aging.Ophthalmology scienceArticle
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Authors and funding
4 authors.
Funding
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Abstract
AII amacrine cells have been found in all mammalian retinas examined and play an important role for visual processing under both scotopic and photopic conditions. Whereas ultrastructural investigations have provided a detailed understanding of synaptic connectivity, there is little information available with respect to quantitative properties and variation of cellular morphology. Here, we performed whole-cell recordings from AII amacrine cells in rat retinal slices and filled the cells with fluorescent dyes. Multi-photon excitation microscopy was used to acquire image stacks and after deconvolution, we performed quantitative morphological reconstruction by computer-aided manual tracing. We reconstructed and performed morphometric analysis on 43 AII amacrine cells, with a focus on branching pattern, dendritic lengths and diameters, surface area, and number and distribution of dendritic varicosities. Compared to previous descriptions, the most surprising result was the considerable extent of branching, with the maximum branch order ranging from approximately 10-40. We found that AII amacrine cells conform to a recently described general structural design principle for neural arbors, where arbor density decreases proportionally to increasing territory size. We confirmed and quantified the bi-stratified morphology of AII amacrine cells by analyzing the arborizations as a function of retinal localization or with Sholl spheres. Principal component and cluster analysis revealed no evidence for morphological subtypes of AII amacrines. These results establish a database of morphometric properties important for studies of development, regeneration, degeneration, and disease processes, as well as a workflow compatible with compartmental modeling.
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