ArticleClinical and translational medicine2016
Shortened leukocyte telomere length in type 2 diabetes mellitus: genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways.
Article in Clinical and translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Metformin exhibits gender specific impact on telomere dynamics by enhancing RAP1 expression in type-2 diabetes mellitus.Acta diabetologica · 2026Article
- The Association of Ramadan Fasting on Relative Leukocyte Telomere Length in Type 2 Diabetes Mellitus.Journal of the ASEAN Federation of Endocrine Societies · 2026Article
- The relationship between telomere length and aging-related diseases.Clinical and experimental medicine · 2025Review
- A Perceived Dissociation Between Systemic Chronic Inflammation, Age, and the Telomere/Telomerase System in Type 2 Diabetes.Biomedicines · 2025Article
- Causal association between telomere length and female reproductive endocrine diseases: a univariable and multivariable Mendelian randomization analysis.Journal of ovarian research · 2024Article
- The inverse association between DNA gaps and HbA1c levels in type 2 diabetes mellitus.Scientific reports · 2023Article
- The Influence ofJournal of clinical medicine · 2023Article
- Associations of levels of peripheral blood leukocyte and subtypes with type 2 diabetes: A longitudinal study of Chinese government employees.Frontiers in endocrinology · 2023Article
- Association study of leukocyte telomere length and genetic polymorphism within hTERT promoter with type 2 diabetes in Bangladeshi population.Molecular biology reports · 2021Article
- Telomere length in different metabolic categories: Clinical associations and modification potential.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Telomere length as a predictor of emotional processing in the brain.Human brain mapping · 2019Article
- Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease.Indian heart journal · 2018Article
- Possible association of the TERT promoter polymorphisms rs2735940, rs7712562 and rs2853669 with diabetes mellitus in obese elderly Polish population: results from the national PolSenior study.Journal of applied genetics · 2018Article
- FTO associations with obesity and telomere length.Journal of biomedical science · 2017Review
- The Telomeric Complex and Metabolic Disease.Genes · 2017Review
- Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage.Scientific reports · 2017Article
- Associations between prediagnostic blood glucose levels, diabetes, and glioma.Scientific reports · 2017Article
- Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length.PloS one · 2017Article
- Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes.Scientific reports · 2016Article
- Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current debate in type 2 diabetes (T2DM) has focused on shortened leukocyte telomere length (LTL) as the result of a number of possible causes, including polymorphisms in mitochondrial uncoupling proteins (UCPs) leading to oxidative stress, telomere regulatory pathway gene polymorphisms, or as a direct result of associated cardiovascular complications inducing tissue organ inflammation and oxidative stress. There is evidence that a heritable shorter telomere trait is a risk factor for development of T2DM. This review discusses the contribution and balance of genetic regulation of UCPs and telomere pathways in the context of T2DM. We discuss genotypes that are well known to influence the shortening of LTL, in particular OBFC1 and telomerase genotypes such as TERC. Interestingly, the interaction between short telomeres and T2DM risk appears to involve mitochondrial dysfunction as an intermediate process. A hypothesis is presented that genetic heterogeneity within UCPs may directly affect oxidative stress that feeds back to influence the fine balance of telomere regulation, cell cycle regulation and diabetes risk and/or metabolic disease progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.