SynthesisCurrent neuropharmacology2016
Methylphenidate on Cognitive Improvement in Patients with Traumatic Brain Injury: A Meta-Analysis.
Synthesis in Current neuropharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Methylphenidate for the cognitive and neurobehavioural sequelae of traumatic brain injury in adults: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Methylphenidate improves executive functions in patients with traumatic brain injuries: a feasibility trial via the idiographic approach.BMC neurology · 2020Trial
- Methylphenidate and Memory and Attention Adaptation Training for Persistent Cognitive Symptoms after Traumatic Brain Injury: A Randomized, Placebo-Controlled Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Efficacy of methylphenidate for the treatment of mental sequelae after traumatic brain injury.Medicine · 2017Trial
- Feasibility, Safety, and Exploratory Outcomes of Methylphenidate for Posttraumatic Stress Disorder Among Patients With Ischemic Stroke.International journal of psychiatry in medicine · 2026Article
- Article
- Medical and Non-Surgical Strategies for Mild Traumatic Brain Injury.Korean journal of neurotrauma · 2026Review
- Potential neuroprotective and therapeutic agents and their mechanisms for irradiation-induced brain injury.Ibrain · 2026Review
- A Mini-review on Unlocking Cognitive Enhancement: An Innovative Strategy for Optimal Brain Functions.Central nervous system agents in medicinal chemistry · 2026Review
- Efficacy of Methylphenidate in Patients With Brain Disease: A Systematic Review and Meta-Analysis.Brain & NeuroRehabilitation · 2025Article
- SK609, a novel dopamine D3 receptor agonist and norepinephrine transporter blocker with putative pro-cognitive actions, does not induce psychostimulant-like increases in risky choice during probabilistic discounting.Psychopharmacology · 2025Article
- The Effect of Methylphenidate on The Consciousness Level of Intoxicated Patients; a Double-Blind Clinical Trial.Archives of academic emergency medicine · 2025Article
- Methylphenidate Ameliorates Behavioural and Neurobiological Deficits in Executive Function for Patients with Chronic Traumatic Brain Injury.Journal of clinical medicine · 2024Article
- "I Feel Happy Again": Methylphenidate Supports Health-Related Quality of Life in Survivors of Pediatric Brain Tumor.Children (Basel, Switzerland) · 2022Article
- Current Clinical Trials in Traumatic Brain Injury.Brain sciences · 2022Review
- Stability of extemporaneously prepared preservative-free methylphenidate 5 mg/mL intravenous solution.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2022Article
- Concussion Incidence and Recovery Among Youth Athletes With ADHD Taking Stimulant-Based Therapy.Orthopaedic journal of sports medicine · 2021Article
- Early IGF-1 Gene Therapy Prevented Oxidative Stress and Cognitive Deficits Induced by Traumatic Brain Injury.Frontiers in pharmacology · 2021Article
- Traumatic brain injury and mood disorders.The mental health clinician · 2020Article
- Neuroimaging of traumatic brain injury in military personnel: An overview.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although methylphenidate has been used as a neurostimulant to treat patients with attention deficit hyperactivity disorder, its therapeutic role in the psychomotor or cognitive recovery of patients with traumatic brain injuries (TBIs) in both intensive care and rehabilitation settings has not been adequately explored. To address this issue, this meta-analysis searched the available electronic databases using the key words "methylphenidate", "brain injuries", "head injuries", and "traumatic brain injury". Analysis of the ten double-blind RCTs demonstrated significant benefit in using methylphenidate for enhancing vigilance-associated attention (i.e., selective, sustained, and divided attention) in patients with TBIs (standardized mean difference: 0.45, 95% CI: 0.10 to 0.79), especially in sustained attention (standardized mean difference: 0.66, 95% CI: 0.22 to 1.10). However, no significant positive impact was noted on the facilitation of memory or processing speed. More studies on the efficacy and safety of methylphenidate for the cognitive improvement of patients with TBIs are warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.