ArticleEndocrine2016
Spontaneous hypoglycemia: diagnostic evaluation and management.
Article in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Hypoglycemia unmasking a giant pulmonary solitary fibrous tumor: a case report.Journal of medical case reports · 2026Article
- Article
- Recurrent Hypoglycemic Coma Episodes Associated With Primary Biliary Cirrhosis.JCEM case reports · 2025Article
- Clopidogrel-induced non-diabetic hypoglycemia reported from Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: a case report.Journal of medical case reports · 2023Article
- Article
- Review
- No Indices of Increased Type 2 Diabetes Risk in Individuals with Reactive Postprandial Hypoglycemia.Metabolites · 2022Article
- Munchausen syndrome with factitious hypoglycemia due to deliberate insulin analog administration and factitious hyperglycemia in a patient with hypothyroidism.Clinical diabetes and endocrinology · 2022Article
- Prevalence and characteristics of factitious hypoglycaemia in non-diabetic patients in a department of endocrinology.Endocrinology, diabetes & metabolism · 2022Article
- Hypoglycemia secondary to insulinoma masking the onset of type 1 diabetes in an adolescent.Clinical case reports · 2021Article
- Article
- Early Morning QT Prolongation During Hypoglycemia: Only a Matter of Glucose?Frontiers in cardiovascular medicine · 2021Article
- Selenium deficiency is linearly associated with hypoglycemia in healthy adults.Redox biology · 2020Article
- A simple formula to correct for the effects of storage time and temperature on the insulin concentration.Journal of clinical laboratory analysis · 2020Article
- Article
- Insulin-induced autoimmune syndrome: A case report.Experimental and therapeutic medicine · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous hypoglycemia is a puzzling clinical problem and an important reason for referral to endocrinologists. Several clinical conditions such as insulinomas, non-insulinoma pancreatogenous hypoglycemia syndrome, insulin autoimmune syndrome, postprandial hypoglycemia (reactive hypoglycemia), non-islet cell tumor hypoglycemia, primary adrenal insufficiency, hypopituitarism, and critical illness can be associated with spontaneous hypoglycemia. Rarely, in patients with mental health issues, factious hypoglycemia from extrinsic insulin use or ingestion of oral hypoglycemic agents can obfuscate the clinical picture for clinicians trying to identify an organic cause. In those presenting with Whipple's triad (symptoms ± signs of hypoglycemia, low plasma glucose, and resolution symptoms ± signs after hypoglycemia correction), a 72-h supervised fast test with measurement of plasma insulin, c-peptide, pro-insulin, and beta-hydroxybutyrate levels, coupled with plasma/urine sulphonylurea screen, forms the first step in diagnostic evaluation. A mixed meal test is preferable for those with predominantly postprandial symptoms. Additional non-invasive and/or invasive diagnostic evaluation is necessary if an organic hypoglycemic disorder is suspected. With the aid of a few brief clinical case scenarios, we discuss the diagnostic evaluation and management of spontaneous hypoglycemia through this comprehensive article.
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