ArticleEndocrine2017
Certain HLA alleles are associated with stress-triggered Graves' disease and influence its course.
Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Significance of HLA in Graves' disease and Graves' orbitopathy in Asian and Caucasian populations - a systematic review.Frontiers in immunology · 2023Pooled it
- Effect of Addition of Thyroxine in the Treatment of Graves' Disease: A Systematic Review.Frontiers in endocrinology · 2020Pooled it
- Associations Between Clinical Manifestations of SARS-CoV-2 Infection and HLA Alleles in a Caucasian Population: A Molecular HLA Typing Study.Journal of clinical medicine · 2024Article
- HLA Class II Allele Groups Involved in Autoimmune Thyroid Diseases: Hashimoto's Thyroiditis and Basedow-Graves Disease.Life (Basel, Switzerland) · 2024Article
- Effect of methimazole treatment on Th1, Th17, and Th22 lymphocytes in pediatric Graves' disease patients.Frontiers in immunology · 2024Article
- Article
- Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2023Article
- Significance of HLA in the development of Graves' orbitopathy.Genes and immunity · 2023Article
- Evolution of Graves' Disease during Immune Reconstitution following Nonmyeloablative Haploidentical Peripheral Blood Stem Cell Transplantation in a Boy Carrying GermlineInternational journal of molecular sciences · 2022Article
- Actual Associations between HLA Haplotype and Graves' Disease Development.Journal of clinical medicine · 2022Article
- Autoimmune thyroid disease following hematopoietic stem cell transplantation in childhood cancer survivors.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2022Article
- Article
- Strong Correlation between HLA and Clinical Course of Subacute Thyroiditis-A Report of the Three Siblings.Genes · 2020Article
- The various faces of hyperthyroidism.Journal of clinical & translational endocrinology · 2020Article
- Heterogenous biochemical expression of hormone activity in subclinical/overt hyperthyroidism and exogenous thyrotoxicosis.Journal of clinical & translational endocrinology · 2020Article
- Graves' disease and mental disorders.Journal of clinical & translational endocrinology · 2020Review
- Subacute Thyroiditis is Associated withJournal of clinical medicine · 2020Article
- Eosinophil/Monocyte Ratio Combined With Serum Thyroid Hormone for Distinguishing Graves' Disease and Subacute Thyroiditis.Frontiers in endocrinology · 2020Article
- Chemokines in hyperthyroidism.Journal of clinical & translational endocrinology · 2019Review
- Thyroid vascularization is an important ultrasonographic parameter in untreated Graves' disease patients.Journal of clinical & translational endocrinology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are no studies on HLA analysis in patients in whom Graves' disease (GD) hyperthyroidism has been preceded by ≥1 stressful event. The aim of the present study was to identify predisposing or protecting HLA alleles and their effects on the course of GD in this subset of patients. We performed serological HLA typing in 58 Caucasian patients with stress-related GD and in 130 matched healthy controls (HC). We also performed genomic HLA typing in 20/58 patients and in all HC. Five HLA alleles and three loci were more frequent in patients compared to HC: B8, Cw7, C*07, C*17, DR3, DR4, DRB1*04, and DQ2. In contrast, B14 was less frequent in patients than in HC. Depending on outcome after ATD withdrawal (remission, exacerbation on-ATD, relapse off-ATD), in patients, some alleles/loci were over-represented, while others were under-represented. Age, FT3, and FT4 fold increase over the upper normal limit at onset were different depending on the allele/locus carried. In GD patients with stress-triggered hyperthyroidism, HLA typing may be helpful in predicting the outcome of the disease after ATD withdrawal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.