ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2016
Esophageal contractions in type 3 achalasia esophagus: simultaneous or peristaltic?
Article in American journal of physiology. Gastrointestinal and liver physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Esophageal anatomy and physiology vary across spastic and non-spastic phenotypes of disorders of esophagogastric junction outflow.Neurogastroenterology and motility · 2024Article
- Why so Many Patients With Dysphagia Have Normal Esophageal Function Testing.Gastro hep advances · 2024Article
- Mini-review: Tailored per-oral endoscopic myotomy for type III achalasia.Neurogastroenterology and motility · 2023Review
- Diagnostic methods to measure spastic segment and guide tailored myotomy length in type 3 achalasia.Neurogastroenterology and motility · 2023Article
- Impaired sliding between the lower esophageal sphincter and crural diaphragm (esophageal hiatus) in patients with achalasia esophagus.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Type II achalasia with focal elevated pressures: A distinct manometric and clinical sub-group.Neurogastroenterology and motility · 2022Article
- Distension contraction plots of pharyngeal/esophageal peristalsis: next frontier in the assessment of esophageal motor function.American journal of physiology. Gastrointestinal and liver physiology · 2022Review
- Achalasia.Nature reviews. Disease primers · 2022Review
- Esophageal Motility Disorders: Current Approach to Diagnostics and Therapeutics.Gastroenterology · 2022Review
- Morphologic Changes in Esophageal Body Movement During Bolus Transport After Peroral Endoscopic Myotomy in Type III Achalasia.Journal of neurogastroenterology and motility · 2022Article
- Distension-contraction profile of peristalsis in patients with nutcracker esophagus.Neurogastroenterology and motility · 2021Article
- Estimation of mechanical work done to open the esophagogastric junction using functional lumen imaging probe panometry.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Assessment of esophageal body peristaltic work using functional lumen imaging probe panometry.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Value of Multidetector Computed Tomography in the Assessment of Achalasia Subtypes and Detection of Pulmonary and Thoracic Complications.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2019Article
- Genesis of Esophageal Pressurization and Bolus Flow Patterns in Patients With Achalasia Esophagus.Gastroenterology · 2018Observational
- Mechanisms of repetitive retrograde contractions in response to sustained esophageal distension: a study evaluating patients with postfundoplication dysphagia.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Functional restoration of the esophagus after peroral endoscopic myotomy for achalasia.PloS one · 2017Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Absence of peristalsis and impaired relaxation of lower esophageal sphincter are the hallmarks of achalasia esophagus. Based on the pressurization patterns, achalasia has been subdivided into three subtypes. The goal of our study was to evaluate the esophageal contraction pattern and bolus clearance in type 3 achalasia esophagus. High-resolution manometry (HRM) recordings of all patients diagnosed with achalasia esophagus in our center between the years 2011 and 2013 were reviewed. Recordings of 36 patients with type 3 achalasia were analyzed for the characteristics of swallow-induced "simultaneous esophageal contraction." The HRM impedance recordings of 14 additional patients with type 3 achalasia were analyzed for bolus clearance from the impedance recording. Finally, the HRM impedance along with intraluminal ultrasound imaging was conducted in six patients to further characterize the simultaneous esophageal contractions. Among 187 achalasia patients, 30 were type 1, 121 type 2, and 36 type 3. A total of 434 swallows evaluated in type 3 achalasia patients revealed that 95% of the swallow-induced contractions met criteria for simultaneous esophageal contraction, based on the onset of contraction. Interestingly, the peak and termination of the majority of simultaneous esophageal contractions were sequential. The HRM impedance revealed that 94% of the "simultaneous contractions" were associated with complete bolus clearance. Ultrasound image analysis revealed that baseline muscle thickness of patients in type 3 achalasia is larger than normal but the pattern of axial shortening is similar to that in normal subjects. The majority of esophageal contractions in type 3 achalasia are not true simultaneous contractions because the peak and termination of contraction are sequential and they are associated with complete bolus clearance.
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