ArticlePloS one2016
Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium.
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Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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47citing papers in PubMed, 3 pooled it
12.0field-weighted citation impact, top 1% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Pooled it
- Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.Circulation. Genomic and precision medicine · 2019Pooled it
- Genomic prediction of coronary heart disease.European heart journal · 2016Pooled it
- Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST).BMC endocrine disorders · 2017Trial
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- Genome-Wide Association Studies of Myocardial Infarction: A Systematic Literature Review.Journal of cardiovascular development and disease · 2026Review
- Metabolomic Signatures of Prediabetes in Mexican Americans: The Role of Genetics and Macronutrients.Advanced genetics (Hoboken, N.J.) · 2025Article
- Big data and cardiovascular risk-insights into obesity, diabetes, and coronary heart disease.Herz · 2025Review
- Alternative Splicing in the Heart: The Therapeutic Potential of Regulating the Regulators.International journal of molecular sciences · 2024Review
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- Phenomics and Robust Multiomics Data for Cardiovascular Disease Subtyping.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- Identification of hsa_circ_0001445 of a novel circRNA-miRNA-mRNA regulatory network as potential biomarker for coronary heart disease.Frontiers in cardiovascular medicine · 2023Article
- Polymorphism rs2383207 of CDKN2B-AS and Susceptibility to Atherosclerosis: A Mini Review.Non-coding RNA · 2022Review
- Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants.Genes & diseases · 2022Review
- Association of Single-Nucleotide Polymorphisms of rs2383206, rs2383207, and rs10757278 With Stroke Risk in the Chinese Population: A Meta-analysis.Frontiers in genetics · 2022Article
- Reproducible disease phenotyping at scale: Example of coronary artery disease in UK Biobank.PloS one · 2022Article
- The genomics of heart failure: design and rationale of the HERMES consortium.ESC heart failure · 2021Article
- Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation.Journal of cardiovascular development and disease · 2021Article
- Polymorphisms of LPA gene, rs1801693 and rs7765781, are not associated with premature myocardial infarction in the Iranian population.ARYA atherosclerosis · 2021Article
- Genetic Variation and Cardiovascular Risk Factors: A Cohort Study on Migrants from the Former Soviet Union and a Native German Population.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
67 authors at 20 institutions in 10 countries.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Charles C WhiteDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America.
Albert Vernon SmithIcelandic Heart Association, Kopavogur, Iceland.
Alanna C MorrisonHuman Genetics Center, and Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, United States of America.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Thomas LumleyDepartment of Biostatistics, University of Washington, Seattle, WA, United States of America.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Brendan M BuckleyDepartment of Pharmacology and Therapeutics, University College, Cork, Ireland.
Jingzhong DingDepartment of Internal Medicine, Division of Geriatrics, Wake Forest University, Winston-Salem, North Carolina, United States of America.
Majken K JensenDepartment of Nutrition, Harvard School of Public Health, Boston, MA, United States of America.
Aaron R FolsomDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, United States of America.
Stephen B KritchevskySticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Cynthia J GirmanDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States of America.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom.
Marcus DörrDZHK (German Center for Cardiovascular Research), partner site, Greifswald, Germany.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Ramachandran S VasanBoston University's and National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, United States of America.
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States of America.
Cara L CartyPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
Jarmo VirtamoNational Institute for Health and Welfare, Helsinki, Finland.
Serkalem DemissieDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America.
Philippe AmouyelDepartment of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France.
Dominique ArveilerDepartment of Epidemiology and Public Health, EA 3430, University of Strasbourg, Strasbourg, France.
Susan R HeckbertCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Jean FerrièresDepartments of Cardiology and Epidemiology, Toulouse University Hospital, Toulouse, France.
Pierre DucimetièreNational Institute of Health and Medical Research (U258), Paris, France.
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, WA, United States of America.
Ying A WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America.
David S SiscovickThe New York Academy of Medicine, New York, NY, United States of America.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, United States of America.
Per-Gunnar WiklundDepartment of Medicine, Umeå University Hospital, Umeå, Sweden.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA, United States of America.
Alun EvansUKCRC Centre of Excellence for Public Health Research (Northern Ireland), Queen's University of Belfast, Belfast, United Kingdom.
Frank KeeUKCRC Centre of Excellence for Public Health Research (Northern Ireland), Queen's University of Belfast, Belfast, United Kingdom.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA, United States of America.
Juha KarvanenNational Institute for Health and Welfare, Helsinki, Finland.
Kari KuulasmaaNational Institute for Health and Welfare, Helsinki, Finland.
Gerardo HeissDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States of America.
Peter KraftDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, United States of America.
Lenore J LaunerLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Marcello R P MarkusDZHK (German Center for Cardiovascular Research), partner site, Greifswald, Germany.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Kaisa SilanderNational Institute for Health and Welfare, Helsinki, Finland.
Peter WagnerNational Institute for Health and Welfare, Helsinki, Finland.
Emelia J BenjaminBoston University's and National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, United States of America.
Kurt LohmanDepartment of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, United States of America.
David J StottInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Tamara B HarrisLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America.
Daniel LevyBoston University's and National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, United States of America.
Yongmei LiuDepartment of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, United States of America.
Eric B RimmDepartment of Nutrition, Harvard School of Public Health, Boston, MA, United States of America.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Henry VölzkeDZHK (German Center for Cardiovascular Research), partner site, Greifswald, Germany.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Stefan BlankenbergDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, Germany.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Eric BoerwinkleHuman Genetics Center, and Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, United States of America.
Christopher J O'DonnellBoston University's and National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, United States of America.
Boston University · USErasmus MC · NLFinnish Institute for Health and Welfare · FIUniversitätsmedizin Greifswald · DEWake Forest University · USBrigham and Women's Hospital · USHarvard University · USNational Heart Lung and Blood Institute · USGroup Health Cooperative · USIcelandic Heart Association · ISLeiden University Medical Center · NLNational Institutes of Health · USQueen's University Belfast · GBThe University of Texas Health Science Center at Houston · USUniversity of Glasgow · GBUniversity of North Carolina at Chapel Hill · USUniversity of Washington · USFramingham Heart Study · USFred Hutch Cancer Center · USHarbor–UCLA Medical Center · US
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MCardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MGenetic analysis of AGES-Reykjavik Study and the Health ABCZIAAG006000 · NIA · NATIONAL INSTITUTE ON AGING · PI HARRIS, TAMARA · 2009 to 2017
$1.3MNCATS NIH HHS UL1 TR000124NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS T32 HL007055NIDDK NIH HHS P30 DK063491
Abstract
backgroundData are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting.
methodsWe performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5×10-6 in Stage I were taken to Stage II for further discovery. Furthermore, in an analysis of prognosis, we studied whether known SNPs from former GWAS were associated with total mortality in individuals who experienced MI during follow-up.
resultsIn Stage I 15 loci passed the threshold of 5×10-6; 8 loci for MI and 8 loci for CHD, for which one locus overlapped and none were reported in previous GWAS meta-analyses. We took 60 SNPs representing these 15 loci to Stage II of discovery. Four SNPs near QKI showed nominally significant association with MI (p-value<8.8×10-3) and three exceeded the genome-wide significance threshold when Stage I and Stage II results were combined (top SNP rs6941513: p = 6.2×10-9). Despite excellent power, the 9p21 locus SNP (rs1333049) was only modestly associated with MI (HR = 1.09, p-value = 0.02) and marginally with CHD (HR = 1.06, p-value = 0.08). Among an inception cohort of those who experienced MI during follow-up, the risk allele of rs1333049 was associated with a decreased risk of subsequent mortality (HR = 0.90, p-value = 3.2×10-3).
conclusionsQKI represents a novel locus that may serve as a predictor of incident CHD in prospective studies. The association of the 9p21 locus both with increased risk of first myocardial infarction and longer survival after MI highlights the importance of study design in investigating genetic determinants of complex disorders.
Indexed as
Genome-Wide Association StudyAgedCohort StudiesCooperative BehaviorCoronary Artery DiseaseFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedMyocardial InfarctionPolymorphism, Single NucleotideProspective Studies
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