Trial reportPloS one2016
Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Immunosenescence and cancer predisposition in pediatric transplant recipients: An emerging paradigm.World journal of transplantation · 2026Review
- Unsupervised Immune Profiling Identifies Distinct Post-Transplant T-Cell Clusters Associated with Kidney Allograft Function.Medical sciences (Basel, Switzerland) · 2026Article
- T-cell immune status in patients with acute exacerbation of chronic obstructive pulmonary disease: a case-control study.Frontiers in medicine · 2025Article
- Characterization of peripheral immune cells in kidney transplantation recipients under different immunosuppressive treatments.Frontiers in immunology · 2025Article
- Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction.Drugs & aging · 2024Review
- Older age is associated with a distinct and marked reduction of functionality of both alloreactive CD4+ and CD8+ T cells.Frontiers in immunology · 2024Article
- Polyfunctional donor-reactive T cells are associated with acute T-cell-mediated rejection of the kidney transplant.Clinical and experimental immunology · 2023Article
- Lowering maintenance immune suppression in elderly kidney transplant recipients; connecting the immunological and clinical dots.Frontiers in medicine · 2023Review
- Article
- Effect of panel reactive antibodies on T cell immunity reinstatement following renal transplantation.World journal of transplantation · 2022Article
- Article
- Chronic Kidney Failure Provokes the Enrichment of Terminally Differentiated CD8Frontiers in immunology · 2022Article
- Article
- Uremia-Associated Immunological Aging and Severity of COVID-19 Infection.Frontiers in medicine · 2021Review
- Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant.Frontiers in immunology · 2021Article
- Review
- A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation.Immunity & ageing : I & A · 2020Article
- Pre-transplant Thymic Function Predicts Is Associated With Patient Death After Kidney Transplantation.Frontiers in immunology · 2020Article
- Article
- Pretransplant transcriptomic signature in peripheral blood predicts early acute rejection.JCI insight · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnd-stage renal disease patients have a dysfunctional, prematurely aged peripheral T-cell system. Here we hypothesized that the degree of premature T-cell ageing before kidney transplantation predicts the risk for early acute allograft rejection (EAR).
methods222 living donor kidney transplant recipients were prospectively analyzed. EAR was defined as biopsy proven acute allograft rejection within 3 months after kidney transplantation. The differentiation status of circulating T cells, the relative telomere length and the number of CD31+ naive T cells were determined as T-cell ageing parameters.
resultsOf the 222 patients analyzed, 30 (14%) developed an EAR. The donor age and the historical panel reactive antibody score were significantly higher (p = 0.024 and p = 0.039 respectively) and the number of related donor kidney transplantation was significantly lower (p = 0.018) in the EAR group. EAR-patients showed lower CD4+CD28null T-cell numbers (p<0.01) and the same trend was observed for CD8+CD28null T-cell numbers (p = 0.08). No differences regarding the other ageing parameters were found. A multivariate Cox regression analysis showed that higher CD4+CD28null T-cell numbers was associated with a lower risk for EAR (HR: 0.65, p = 0.028). In vitro, a significant lower percentage of alloreactive T cells was observed within CD28null T cells (p<0.001).
conclusionImmunological ageing-related expansion of highly differentiated CD28null T cells is associated with a lower risk for EAR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.