Evidence map›Paper›PMID 26950683›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2016

Effects of Transdermal Testosterone Gel or an Aromatase Inhibitor on Prostate Volume in Older Men.

Jenny Pena Dias, Denise Melvin, Michelle Shardell, Luigi Ferrucci, Chee W Chia, Mohsen Gharib, Josephine M Egan, Shehzad Basaria

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Sarcopenia in chronic kidney disease: from bench to bedside.The Korean journal of internal medicine · 2023
    Review
  7. Article
  8. Review
  9. Advances in research on pharmacotherapy of sarcopenia.Aging medicine (Milton (N.S.W)) · 2021
    Review
  10. Article
  11. Observational
  12. Adverse Effects of Aromatase Inhibition on the Brain and Behavior in a Nonhuman Primate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jenny Pena DiasLaboratory of Clinical Investigation (J.P.D., D.M., J.M.E.) and Translational Gerontology Branch (M.S., L.F., C.W.C.), National Institute on Aging, and Imaging Section (M.G.), Medstar Harbor Hospital, Baltimore, Maryland 21225; and Section on Men's Health, Aging, and Metabolism (S.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Denise MelvinLaboratory of Clinical Investigation (J.P.D., D.M., J.M.E.) and Translational Gerontology Branch (M.S., L.F., C.W.C.), National Institute on Aging, and Imaging Section (M.G.), Medstar Harbor Hospital, Baltimore, Maryland 21225; and Section on Men's Health, Aging, and Metabolism (S.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Michelle ShardellLaboratory of Clinical Investigation (J.P.D., D.M., J.M.E.) and Translational Gerontology Branch (M.S., L.F., C.W.C.), National Institute on Aging, and Imaging Section (M.G.), Medstar Harbor Hospital, Baltimore, Maryland 21225; and Section on Men's Health, Aging, and Metabolism (S.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Luigi FerrucciLaboratory of Clinical Investigation (J.P.D., D.M., J.M.E.) and Translational Gerontology Branch (M.S., L.F., C.W.C.), National Institute on Aging, and Imaging Section (M.G.), Medstar Harbor Hospital, Baltimore, Maryland 21225; and Section on Men's Health, Aging, and Metabolism (S.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Chee W ChiaLaboratory of Clinical Investigation (J.P.D., D.M., J.M.E.) and Translational Gerontology Branch (M.S., L.F., C.W.C.), National Institute on Aging, and Imaging Section (M.G.), Medstar Harbor Hospital, Baltimore, Maryland 21225; and Section on Men's Health, Aging, and Metabolism (S.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Mohsen GharibLaboratory of Clinical Investigation (J.P.D., D.M., J.M.E.) and Translational Gerontology Branch (M.S., L.F., C.W.C.), National Institute on Aging, and Imaging Section (M.G.), Medstar Harbor Hospital, Baltimore, Maryland 21225; and Section on Men's Health, Aging, and Metabolism (S.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Josephine M EganLaboratory of Clinical Investigation (J.P.D., D.M., J.M.E.) and Translational Gerontology Branch (M.S., L.F., C.W.C.), National Institute on Aging, and Imaging Section (M.G.), Medstar Harbor Hospital, Baltimore, Maryland 21225; and Section on Men's Health, Aging, and Metabolism (S.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Shehzad BasariaLaboratory of Clinical Investigation (J.P.D., D.M., J.M.E.) and Translational Gerontology Branch (M.S., L.F., C.W.C.), National Institute on Aging, and Imaging Section (M.G.), Medstar Harbor Hospital, Baltimore, Maryland 21225; and Section on Men's Health, Aging, and Metabolism (S.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

Funding

The effects of aromatase inhibition in older men with hypogonadismZIAAG000974 · NIA · NATIONAL INSTITUTE ON AGING · PI CHIA, CHEE W · 2009 to 2016
$2.7M
6 · The paper itself

Abstract

contextT replacement is being increasingly offered to older men with age-related low T; hence, monitoring prostate health is important during T therapy. Data suggest that estrogens have an independent effect on the prostate and some effects of T on the prostate might be mediated via its aromatization to estradiol. Although some studies have assessed the effects of T replacement on prostate volume, the differential effects of T and estradiol have not been delineated.

objectiveThe objective of the study was to investigate the relative effects of T and estradiol on prostate volume in older men with low T.

participantsThirty-one men, 65 years old or older with total T less than 350 ng/dL (measured by mass spectrometry) participated in the study.

interventionThe intervention included randomization to 5 g transdermal T gel (TT), 1 mg oral aromatase inhibitor (AI), or placebo daily for 12 months.

main outcome measuresThe primary outcome was prostate volume measured by transrectal ultrasound at baseline and 12 months. Secondary outcomes included prostate-specific antigen levels and lower urinary tract symptoms score.

resultsSerum T levels increased in both intervention groups; estradiol levels increased in the TT group, whereas it decreased in the AI group. At 12 months, prostate volume significantly increased (4.5 ± 1.76 cc, P < .05) only in the TT group. Increase in prostate-specific antigen levels were seen in both intervention groups at 6 months (P < .01 and P < .001). The lower urinary tract symptoms score increased only in the TT group (P < .05).

conclusionsThe tropic effects of T on the prostate are mediated via its aromatization to estradiol. Administration of AI for 12 months to older men was not detrimental to the prostate.

Indexed as

Administration, CutaneousAgedAged, 80 and overAnastrozoleAromatase InhibitorsDouble-Blind MethodHumansMaleNitrilesOrgan SizeProstateTestosteroneTreatment OutcomeTriazolesUltrasonographyAnastrozoleAromatase InhibitorsNitrilesTestosteroneTriazoles

Identifiers

PMID26950683
PMCPMC4880169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.