ArticlePloS one2016
Prenatal Air Pollution Exposure and Early Cardiovascular Phenotypes in Young Adults.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies.Particle and fibre toxicology · 2020Pooled it
- Early life cookstove interventions and children's blood pressure: Evidence from the Ghana randomized air pollution and health study.Environmental research · 2025Trial
- Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Air pollution and depression symptoms in middle-aged and older adults in Los Angeles County.International archives of occupational and environmental health · 2025Article
- The association of prenatal ambient air pollution with placental epigenetic gestational age at birth.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Durational Exposure to Particulate Matter and Changes in Fertility Intentions: A Study of Adults in China.Current medical science · 2025Article
- Impact of childhood exposure to traffic related air pollution on adult cardiometabolic health: Exploring the role of perceived stress.Environmental research · 2024Article
- Long-term exposure to ambient air pollution and measures of central hemodynamics and arterial stiffness among multiethnic Chicago residents.Environmental health : a global access science source · 2024Article
- The association of in-utero exposure to air pollution and atherogenic index of plasma in newborns.Environmental health : a global access science source · 2024Article
- Evaluation of common carotid artery wall stiffness by shear wave elastography in smokers and non-smokers.Tobacco induced diseases · 2024Article
- Air pollution, dementia, and lifespan in the socio-economic gradient of aging: perspective on human aging for planning future experimental studies.Frontiers in aging · 2023Article
- Quantile regression to examine the association of air pollution with subclinical atherosclerosis in an adolescent population.Environment international · 2022Article
- Ambient air pollution during pregnancy and cardiometabolic biomarkers in cord blood.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- On Placental Toxicology Studies and Cerium Dioxide Nanoparticles.International journal of molecular sciences · 2021Review
- Review
- Cerebral cortex and blood transcriptome changes in mouse neonates prenatally exposed to air pollution particulate matter.Journal of neurodevelopmental disorders · 2021Article
- Childhood traffic-related air pollution and adverse changes in subclinical atherosclerosis measures from childhood to adulthood.Environmental health : a global access science source · 2021Article
- In Utero Exposure to Particulate Air Pollution during Pregnancy: Impact on Birth Weight and Health through the Life Course.International journal of environmental research and public health · 2020Review
- Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution.Journal of the American Heart Association · 2020Review
- Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?Clinical epigenetics · 2019Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Exposure to ambient air pollutants increases risk for adverse cardiovascular health outcomes in adults. We aimed to evaluate the contribution of prenatal air pollutant exposure to cardiovascular health, which has not been thoroughly evaluated. The Testing Responses on Youth (TROY) study consists of 768 college students recruited from the University of Southern California in 2007-2009. Participants attended one study visit during which blood pressure, heart rate and carotid artery arterial stiffness (CAS) and carotid artery intima-media thickness (CIMT) were assessed. Prenatal residential addresses were geocoded and used to assign prenatal and postnatal air pollutant exposure estimates using the U.S. Environmental Protection Agency's Air Quality System (AQS) database. The associations between CAS, CIMT and air pollutants were assessed using linear regression analysis. Prenatal PM10 and PM2.5 exposures were associated with increased CAS. For example, a 2 SD increase in prenatal PM2.5 was associated with CAS indices, including a 5% increase (β = 1.05, 95% CI 1.00-1.10) in carotid stiffness index beta, a 5% increase (β = 1.05, 95% CI 1.01-1.10) in Young's elastic modulus and a 5% decrease (β = 0.95, 95% CI 0.91-0.99) in distensibility. Mutually adjusted models of pre- and postnatal PM2.5 further suggested the prenatal exposure was most relevant exposure period for CAS. No associations were observed for CIMT. In conclusion, prenatal exposure to elevated air pollutants may increase carotid arterial stiffness in a young adult population of college students. Efforts aimed at limiting prenatal exposures are important public health goals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.