Evidence map›Paper›PMID 26950124›Full record

ReviewInternational journal of molecular sciences2016

Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases.

Meng Li, Ping Gao, Junping Zhang

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Lysosomes as a Target of Anticancer Therapy.International journal of molecular sciences · 2023
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Meng LiGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. zhongyilimeng@163.com.
Ping GaoDepartment of Medical Imaging, Urumqi General Hospital of Lanzhou Military Area Command, Urumqi 830000, China. doctorgaoping@sina.com.
Junping ZhangDepartment of cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medcine, Tianjin 300192, China. tjzhtcm@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is a cell survival process which is related to breaking down and reusing cytoplasm components. Moreover, autophagy regulates cell death under certain conditions. Apoptosis has the characteristics of chromatin agglutination and the shrinking of nuclear and apoptosis body form. Even if the mechanisms of autophagy and apoptosis have differences, some proteins modulate both autophagy and apoptosis. Crosstalk between them exists. This review highlights recent advances in the interaction of autophagy and apoptosis and its importance in the development of cardiovascular diseases.

Indexed as

ApoptosisAutophagySignal TransductionAnimalsAutophagy-Related ProteinsBeclin-1Cardiovascular DiseasesCardiovascular SystemCaspasesHumansMolecular Targeted TherapyProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53Autophagy-Related ProteinsBeclin-1CaspasesProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53apoptosisautophagycardiovascular diseasescrosstalk

Identifiers

PMID26950124
PMCPMC4813194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.