ReviewInternational journal of molecular sciences2016
Biomaterials with Antibacterial and Osteoinductive Properties to Repair Infected Bone Defects.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of the osteogenic effect of rare earth nanomaterials and the underlying mechanisms.Journal of nanobiotechnology · 2024Pooled it
- Article
- Dual-Functional Triphasic Composite Scaffolds for Enhanced Antibacterial and Osteogenic Performance in Preventing Osteomyelitis Recurrence.ACS omega · 2026Article
- Review
- Current State of Knowledge Regarding the Treatment of Cranial Bone Defects: An Overview.Materials (Basel, Switzerland) · 2025Review
- Nanohybrid Hydrogel with Dual Functions: Controlled Low-Temperature Photothermal Antibacterial Activity and Promoted Regeneration for Treating MRSA-Infected Bone Defects.Advanced healthcare materials · 2025Article
- Bacterial colonization of bone substitute materials used in oral surgery: mechanisms, clinical implications, and preventive strategies-A narrative review.Frontiers in microbiology · 2025Review
- Anti-Infection Efficacy, Osteogenesis Potential, and Biocompatibility of 3D Printed PLGA/Nano-Hydroxyapatite Porous Scaffolds Grafted with Vancomycin/DOPA/rhBMP-2 in Infected Rabbit Bone Defects.International journal of nanomedicine · 2025Article
- Recent advances of chitosan-based composite hydrogel materials in application of bone tissue engineering.Heliyon · 2024Review
- Targeting Bacteria-Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Advances in Regenerative and Reconstructive Medicine in the Prevention and Treatment of Bone Infections.Biology · 2024Review
- Additive manufacturing of degradable metallic scaffolds for material-structure-driven diabetic maxillofacial bone regeneration.Bioactive materials · 2024Article
- Article
- Article
- Reconstruction of Craniomaxillofacial Bone Defects with 3D-Printed Bioceramic Implants: Scoping Review and Clinical Case Series.Journal of clinical medicine · 2024Article
- Bioactive ceramic-based materials: beneficial properties and potential applications in dental repair and regeneration.Regenerative medicine · 2024Review
- Bone Tissue Engineering and Nanotechnology: A Promising Combination for Bone Regeneration.Biology · 2024Review
- Immobilizing c(RGDfc) on the surface of metal-phenolic networks by thiol-click reaction for accelerating osteointegration of implant.Materials today. Bio · 2024Article
- 3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects.Journal of biological engineering · 2024Article
- Research advances of nanomaterials for the acceleration of fracture healing.Bioactive materials · 2024Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The repair of infected bone defects is still challenging in the fields of orthopedics, oral implantology and maxillofacial surgery. In these cases, the self-healing capacity of bone tissue can be significantly compromised by the large size of bone defects and the potential/active bacterial activity. Infected bone defects are conventionally treated by a systemic/local administration of antibiotics to control infection and a subsequent implantation of bone grafts, such as autografts and allografts. However, these treatment options are time-consuming and usually yield less optimal efficacy. To approach these problems, novel biomaterials with both antibacterial and osteoinductive properties have been developed. The antibacterial property can be conferred by antibiotics and other novel antibacterial biomaterials, such as silver nanoparticles. Bone morphogenetic proteins are used to functionalize the biomaterials with a potent osteoinductive property. By manipulating the carrying modes and release kinetics, these biomaterials are optimized to maximize their antibacterial and osteoinductive functions with minimized cytotoxicity. The findings, in the past decade, have shown a very promising application potential of the novel biomaterials with the dual functions in treating infected bone defects. In this review, we will summarize the current knowledge of novel biomaterials with both antibacterial and osteoinductive properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.