ReviewAmerican journal of respiratory cell and molecular biology2016
Obesity and Asthma: Microbiome-Metabolome Interactions.
Review in American journal of respiratory cell and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Bidirectional Association Between Asthma and Obesity During Childhood and Adolescence: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies.Metabolomics : Official journal of the Metabolomic Society · 2019Pooled it
- Multiomic Analysis of the Gut Microbiome and Serum Metabolome in Response to a Low-Carbohydrate, High-Protein Diet in Individuals With Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2025Trial
- Metabolic dysfunction associated steatotic liver disease is associated with an increased risk of multiple respiratory system diseases.Scientific reports · 2025Article
- Gut microbiota-metabolome crosstalk in allergic diseases: mechanistic insights and translational opportunities.Frontiers in allergy · 2025Review
- Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota.iMeta · 2024Review
- Sputum microbiota and inflammatory subtypes in asthma, COPD, and its overlap.The journal of allergy and clinical immunology. Global · 2024Article
- Bibliometric Insights into Research Hotspots and Trends in Obesity and Asthma from 2013 to 2023.Obesity facts · 2024Article
- Obesity-associated Airway Hyperresponsiveness: Mechanisms Underlying Inflammatory Markers and Possible Pharmacological Interventions.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Anti-inflammatory effects of reticuline on the JAK2/STAT3/SOCS3 and p38 MAPK/NF-κB signaling pathway in a mouse model of obesity-associated asthma.The clinical respiratory journal · 2024Article
- Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics.International journal of molecular sciences · 2023Review
- Review
- Mediterranean Diet and Airway Inflammation in School-Aged Children.Children (Basel, Switzerland) · 2023Article
- Metabolic Contributions to Pathobiology of Asthma.Metabolites · 2023Review
- Obesity-related asthma in children and adolescents.The Lancet. Child & adolescent health · 2022Review
- Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma.Autophagy · 2022Article
- It takes guts to learn: machine learning techniques for disease detection from the gut microbiome.Emerging topics in life sciences · 2021Review
- Pharmaco-Metabolomics of Inhaled Corticosteroid Response in Individuals with Asthma.Journal of personalized medicine · 2021Article
- Review
- Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is a risk factor for asthma, but obese subjects with asthma respond poorly to standard asthma drugs. Obesity also alters gut bacterial community structure. Obesity-related changes in gut bacteria contribute to weight gain and other obesity-related conditions, including insulin resistance and systemic inflammation. Here, we review the rationale for the hypothesis that obesity-related changes in gut bacteria may also play a role in obesity-related asthma. The metabolomes of the liver, serum, urine, and adipose tissue are altered in obesity. Gut bacteria produce a large number of metabolites, which can reach the blood and circulate to other organs, and gut bacteria-derived metabolites have been shown to contribute to disease processes outside the gastrointestinal tract, including cardiovascular disease. Here, we describe the potential roles for two such classes of metabolites in obesity-related asthma: short-chain fatty acids and bile acids. Greater understanding of the role of microbiota in obesity-related asthma could lead to novel microbiota-based treatments for these hard-to-treat patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.