ArticleCurrent opinion in behavioral sciences2016
Mechanisms for motor timing in the cerebellar cortex.
Article in Current opinion in behavioral sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- MeCP2 is Necessary in Cerebellar Purkinje Cells for Precise Network Dynamics During Associative Motor Learning.bioRxiv : the preprint server for biology · 2026Article
- Control Principles of Neural Dynamics Revealed by the Neurobiology of Timing.Annual review of neuroscience · 2025Review
- A cerebellar granule cell-climbing fiber computation to learn to track long time intervals.Neuron · 2024Article
- Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning.PLoS computational biology · 2024Article
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning.Frontiers in computational neuroscience · 2023Article
- Article
- Quantitative properties of the creation and activation of a cell-intrinsic duration-encoding engram.Frontiers in computational neuroscience · 2022Article
- Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses.PLoS computational biology · 2021Article
- Modulation of the dynamics of cerebellar Purkinje cells through the interaction of excitatory and inhibitory feedforward pathways.PLoS computational biology · 2021Article
- A FN-MdV pathway and its role in cerebellar multimodular control of sensorimotor behavior.Nature communications · 2020Article
- Article
- Biologically Plausible Class Discrimination Based Recurrent Neural Network Training for Motor Pattern Generation.Frontiers in neuroscience · 2020Article
- Storage and erasure of behavioural experiences at the single neuron level.Scientific reports · 2019Article
- Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications.Cerebellum (London, England) · 2019Article
- Internal Clocks, mGluR7 and Microtubules: A Primer for the Molecular Encoding of Target Durations in Cerebellar Purkinje Cells and Striatal Medium Spiny Neurons.Frontiers in molecular neuroscience · 2019Article
- Inactivation of the interpositus nucleus blocks the acquisition of conditioned responses and timing changes in conditioning-specific reflex modification of the rabbit eyeblink response.Neurobiology of learning and memory · 2018Article
- Absence of Parallel Fibre to Purkinje Cell LTD During Eyeblink Conditioning.Scientific reports · 2018Article
- How does transient signaling input affect the spike timing of postsynaptic neuron near the threshold regime: an analytical study.Journal of computational neuroscience · 2018Article
- Learned response sequences in cerebellar Purkinje cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In classical eyeblink conditioning a subject learns to blink to a previously neutral stimulus. This conditional response is timed to occur just before an air puff to the eye. The learning is known to depend on the cerebellar cortex where Purkinje cells respond with adaptively timed pauses in their spontaneous firing. The pauses in the inhibitory Purkinje cells cause disinhibition of the cerebellar nuclei, which elicit the overt blinks. The timing of a Purkinje cell response was previously thought to require a temporal code in the input signal but recent work suggests that the Purkinje cells can learn to time their responses through an intrinsic mechanism that is activated by metabotropic glutamate receptors (mGluR7).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.