ArticleInternational journal of ophthalmology2016
C-reactive protein and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus.
Article in International journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Impact of IL-6 receptor inhibitors on cerebrospinal fluid metabolites in type 2 diabetes patients.Medicine · 2026Article
- Evaluation of C-Reactive Protein/Albumin Ratio in Diabetic Retinopathy Patients.Diagnostics (Basel, Switzerland) · 2025Article
- High-Sensitivity C-Reactive Protein and its Association with Diabetic Retinopathy: A Cross-sectional Study.Archives of Iranian medicine · 2025Article
- Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy.Neural regeneration research · 2023Review
- Association between Pro-oxidant-Antioxidant balance and high-sensitivity C-reactive protein in type 2 diabetes mellitus: A Study on Postmenopausal Women.Endocrinology, diabetes & metabolism · 2023Article
- The Association of Retinal age gap with metabolic syndrome and inflammation.Journal of diabetes · 2023Article
- Risk Factors for the Development of Retinopathy in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Experience.Diabetes care · 2022Article
- Emerging insights into the relationship between hyperlipidemia and the risk of diabetic retinopathy.Lipids in health and disease · 2020Review
- Presence of diabetic retinopathy is lower in type 2 diabetic patients with non-alcoholic fatty liver disease.Medicine · 2019Observational
- The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review.International journal of ophthalmology · 2019Article
- Article
- The relationship between insulin resistance/β-cell dysfunction and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus: the Desheng Diabetic Eye Study.International journal of ophthalmology · 2018Article
- The Beijing Desheng Diabetic Eye Study: rationale, design, methodology and baseline data.International journal of ophthalmology · 2018Article
- Aqueous humor pentraxin-3 levels in patients with diabetes mellitus.Eye (London, England) · 2017Article
- Hypermethylation in the promoter of theDiabetology & metabolic syndrome · 2017Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relationship between C-reactive protein (CRP) and diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM).
methodsCommunity-based observational cohort study. There were 1131 participants recruited from November 2009 to September 2011 in Desheng community in urban Beijing. Patients diagnosed T2DM were recruited and underwent a standardized evaluation consisting of a questionnaire, ocular and anthropometric examinations and laboratory investigation. The presence and severity of DR were assessed by seven fields 30° color fundus photographs. Subjects were then classified into groups with no DR, any DR, or vision-threatening DR. CRP was analyzed from serum of study subjects.
resultsA total of 1007 patients with T2DM were included for analysis, including 408 (40.5%) men and 599 (59.5%) women. The median CRP level was 1.5 mg/L for women and 1.1 mg/L for men (P=0.004, OR 0.37, 95% CI 0.18-0.74). After adjusting for possible covariates, higher levels of CRP were associated with lower prevalence of any DR (P=0.02, OR 0.55, 95% CI 0.35-0.89), but not associated with vision-threatening DR (P=0.62, OR 0.78, 95% CI 0.28-2.14). After stratification by sex, the inverse association between CRP and DR was found to be statistically significant in men (P=0.006, OR 0.35, 95% CI 0.16-0.73), but not in women (P=0.58, OR 0.88, 95% CI 0.29-1.16).
conclusionThe data drawn from a Chinese population with T2DM suggest that increasing CRP levels may be inversely associated with development of DR.
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