Evidence map›Paper›PMID 26949518›Full record

ReviewF1000Research2015

A dynamic architecture of life.

Beatrix P Rubin, Jeremy Brockes, Brigitte Galliot, Ueli Grossniklaus, Daniel Lobo, Marco Mainardi, Marie Mirouze, Alain Prochiantz, Angelika Steger

Abstract readReview
In one paragraph

Review in F1000Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Formalizing Phenotypes of Regeneration.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  2. Computational Systems Biology of Morphogenesis.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Beatrix P RubinCollegium Helveticum, University of Zurich and ETH Zurich, Zurich, 8092, Switzerland.
Jeremy BrockesDepartment of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK.
Brigitte GalliotDepartment of Genetics and Evolution, University of Geneva, Geneva, 1211, Switzerland.
Ueli GrossniklausDepartment of Plant and Microbial Biology & Zurich-Basel Plant Science Center, University of Zurich, Zurich, 8008, Switzerland.
Daniel LoboDepartment of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, 21250, USA.
Marco MainardiCNR Neuroscience Institute, 56124 Pisa, Italy; Institute of Human Physiology, Catholic University, 00168 Rome, Italy.
Marie MirouzeInstitut de Recherche pour le Développement, UMR DIADE, Laboratoire Génome et Développement des Plantes, 66860 Perpignan, France.
Alain ProchiantzChaire des Processus Morphogénétiques, Centre Interdisciplinaire de Recherche en Biologie, Paris, 75231, France.
Angelika StegerInstitute of Theoretical Computer Science, ETH Zurich, Zurich, 8092, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent decades, a profound conceptual transformation has occurred comprising different areas of biological research, leading to a novel understanding of life processes as much more dynamic and changeable. Discoveries in plants and animals, as well as novel experimental approaches, have prompted the research community to reconsider established concepts and paradigms. This development was taken as an incentive to organise a workshop in May 2014 at the Academia Nazionale dei Lincei in Rome. There, experts on epigenetics, regeneration, neuroplasticity, and computational biology, using different animal and plant models, presented their insights on important aspects of a dynamic architecture of life, which comprises all organisational levels of the organism. Their work demonstrates that a dynamic nature of life persists during the entire existence of the organism and permits animals and plants not only to fine-tune their response to particular environmental demands during development, but underlies their continuous capacity to do so. Here, a synthesis of the different findings and their relevance for biological thinking is presented.

Indexed as

computational biologydevelopmentlimb regenerationneuroplasticityplant epigeneticsrepair regenerationtissue homeostasis

Identifiers

PMID26949518
PMCPMC4760269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.