Evidence map›Paper›PMID 26949333›Full record

ArticleDrug target insights2016

Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques.

Cristiano Spadaccio, Francesco Nappi, Federico De Marco, Pietro Sedati, Fraser W H Sutherland, Massimo Chello, Marcella Trombetta, Alberto Rainer

Open access · goldAbstract read
In one paragraph

Article in Drug target insights, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  5. Biomechanics of Transcatheter Aortic Valve Implant.Bioengineering (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Cristiano SpadaccioDepartment of Cardiothoracic Surgery, Golden Jubilee National Hospital, Clydebank, Dunbartonshire, UK.
Francesco NappiCardiac Surgery, Centre Cardiologique du Nord de Saint-Denis, Paris, France.
Federico De MarcoLaboratory of Virology, The Regina Elena National Cancer Institute, Rome, Italy.
Pietro SedatiUnit of Imaging and Diagnostics, Università Campus Bio-Medico di Roma, Rome, Italy.
Fraser W H SutherlandDepartment of Cardiothoracic Surgery, Golden Jubilee National Hospital, Clydebank, Dunbartonshire, UK.
Massimo ChelloUnit of Cardiac Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Marcella TrombettaTissue Engineering Laboratory, Università Campus Bio-Medico di Roma, Rome, Italy.
Alberto RainerTissue Engineering Laboratory, Università Campus Bio-Medico di Roma, Rome, Italy.
Università Campus Bio-Medico · ITCentre Cardiologique du Nord · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we tested in vivo effectiveness of a previously developed poly-l-lactide/poly-ε-caprolactone armored vascular graft releasing heparin. This bioprosthesis was designed in order to overcome the main drawbacks of tissue-engineered vascular grafts, mainly concerning poor mechanical properties, thrombogenicity, and endothelialization. The bioprosthesis was successfully implanted in an aortic vascular reconstruction model in rabbits. All grafts implanted were patent at four weeks postoperatively and have been adequately populated by endogenous cells without signs of thrombosis or structural failure and with no need of antiplatelet therapy. The results of this preliminary study might warrant for further larger controlled in vivo studies to further confirm these findings.

Indexed as

additive manufacturingcomputer-aided tissue engineeringdrug releaseelectrospinningheparinvascular graft

Identifiers

PMID26949333
PMCPMC4772909
OpenAlexW2283499874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.