ArticleeLife2016
Acquisition of exogenous haem is essential for tick reproduction.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed.
- Genomic Evolution of Francisella: Metabolic Innovation, Endosymbiotic Transitions to Ticks, and Biogeographic History.Genome biology and evolution · 2026Article
- RNAi-mediated knockdown of the poultry red mite cathepsin D-1 impacts haemoglobin digestion.Parasites & vectors · 2026Article
- Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide-susceptible and resistant strains.Pest management science · 2026Article
- Smolstatin1, a unique cystatin-like stefin ofCurrent research in microbial sciences · 2026Article
- Disruption of chitin synthases impairs tick feeding and reproduction, validating a broad-spectrum acaricide target.Frontiers in cellular and infection microbiology · 2026Article
- Evolutionary Convergence of Nutritional Symbionts in Ticks.Environmental microbiology reports · 2025Article
- Transcriptomic analysis of Rhipicephalus microplus hemocytes from female ticks infected with Babesia bovis or Babesia bigemina.Parasites & vectors · 2025Article
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- Article
- Metatranscriptomics provide insights into the role of the symbiont Midichloria mitochondrii in Ixodes ticks.FEMS microbiology ecology · 2024Article
- Hooked on fish blood: the reliance of a gill parasite on haematophagy.Proceedings. Biological sciences · 2024Article
- A longitudinal transcriptomic analysis of Rhipicephalus microplus midgut upon feeding.Ticks and tick-borne diseases · 2024Article
- Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome.Molecular & cellular proteomics : MCP · 2023Article
- Article
- A NovelMicroorganisms · 2023Article
- Notes from the Underground: Heme Homeostasis inBiomolecules · 2023Review
- A longitudinal transcriptomic analysis from unfed to post-engorgement midguts of adult female Ixodes scapularis.Scientific reports · 2023Review
- PERK-mediated antioxidant response is key for pathogen persistence in ticks.bioRxiv : the preprint server for biology · 2023Article
- Blood-feeding adaptations and virome assessment of the poultry red mite Dermanyssus gallinae guided by RNA-seq.Communications biology · 2023Article
- Preliminary Study on Artificial versus Animal-Based Feeding Systems forMicroorganisms · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haem and iron homeostasis in most eukaryotic cells is based on a balanced flux between haem biosynthesis and haem oxygenase-mediated degradation. Unlike most eukaryotes, ticks possess an incomplete haem biosynthetic pathway and, together with other (non-haematophagous) mites, lack a gene encoding haem oxygenase. We demonstrated, by membrane feeding, that ticks do not acquire bioavailable iron from haemoglobin-derived haem. However, ticks require dietary haemoglobin as an exogenous source of haem since, feeding with haemoglobin-depleted serum led to aborted embryogenesis. Supplementation of serum with haemoglobin fully restored egg fertility. Surprisingly, haemoglobin could be completely substituted by serum proteins for the provision of amino-acids in vitellogenesis. Acquired haem is distributed by haemolymph carrier protein(s) and sequestered by vitellins in the developing oocytes. This work extends, substantially, current knowledge of haem auxotrophy in ticks and underscores the importance of haem and iron metabolism as rational targets for anti-tick interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.