ArticleScientific reports2016
The identification of age-associated cancer markers by an integrative analysis of dynamic DNA methylation changes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Association ofTranslational cancer research · 2026Article
- On the thermodynamics of DNA methylation process.Scientific reports · 2023Article
- Three-dimensional genome landscape comprehensively reveals patterns of spatial gene regulation in papillary and anaplastic thyroid cancers: a study using representative cell lines for each cancer type.Cellular & molecular biology letters · 2023Article
- Methylated Septin9 (mCancer research communications · 2022Article
- Optimal sample size for calibrating DNA methylation age estimators.Molecular ecology resources · 2021Article
- Integrating Multi-Omics Data for Gene-Environment Interactions.Biotech (Basel (Switzerland)) · 2021Article
- Relationship between DLEC1 and PBX3 promoter methylation and the risk and prognosis of gastric cancer in peripheral blood leukocytes.Journal of cancer research and clinical oncology · 2020Article
- Potential Salivary mRNA Biomarkers for Early Detection of Oral Cancer.Journal of clinical medicine · 2020Article
- DNA Methylation Markers for Breast Cancer Detection in the Developing World.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Clinical significance of aberrant DEUP1 promoter methylation in hepatocellular carcinoma.Oncology letters · 2019Article
- Microbiome Multi-Omics Network Analysis: Statistical Considerations, Limitations, and Opportunities.Frontiers in genetics · 2019Review
- CancerClock: A DNA Methylation Age Predictor to Identify and Characterize Aging Clock in Pan-Cancer.Frontiers in bioengineering and biotechnology · 2019Article
- Article
- MethBank 3.0: a database of DNA methylomes across a variety of species.Nucleic acids research · 2018Article
- The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population.PloS one · 2017Article
- Determination of epigenetic age through DNA methylation of NPTX2 gene using buccal scrapes: A pilot study.Journal of forensic dental sciencesArticle
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As one of the most widely studied epigenetic modifications, DNA methylation has an important influence on human traits and cancers. Dynamic variations in DNA methylation have been reported in malignant neoplasm and aging; however, the mechanisms remain poorly understood. By constructing an age-associated and cancer-related weighted network (ACWN) based on the correlation of the methylation level and the protein-protein interaction, we found that DNA methylation changes associated with age were closely related to the occurrence of cancer. Additional analysis of 102 module genes mined from the ACWN revealed discrimination based on two main patterns. One pattern involved methylation levels that increased with aging and were higher in cancer patients compared with normal controls (HH pattern). The other pattern involved methylation levels that decreased with aging and were lower in cancer compared with normal (LL pattern). Upon incorporation with gene expression levels, 25 genes were filtered based on negative regulation by DNA methylation. These genes were regarded as potential cancer risk markers that were influenced by age in the process of carcinogenesis. Our results will facilitate further studies regarding the impact of the epigenetic effects of aging on diseases and will aid in the development of tailored cancer preventive strategies.
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