Evidence map›Paper›PMID 26949170›Full record

ArticleStress (Amsterdam, Netherlands)2016

Documenting stress in caregivers of transplantation patients: initial evidence of HPA dysregulation.

Margaret F Bevans, Alyson Ross, Leslie Wehrlen, Stephen D Klagholz, Li Yang, Richard Childs, Sharon L Flynn, Alan T Remaley, Michael Krumlauf, Robert N Reger and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stress (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. An evidence-based stress management intervention for allogeneic hematopoietic stem cell transplant caregivers: development, feasibility and acceptability.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Trial
  7. Article
  8. Review
  9. Article
  10. Article
  11. Association between inflammatory cytokines and caregiving distress in family caregivers of cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Quality of Life of Caregivers of Hematopoietic Cell Transplant Recipients.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2018
    Article
  16. Article
  17. National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Patient-Centered Outcomes Working Group Report.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Margaret F Bevansa National Institutes of Health Clinical Center , Bethesda , MD , USA .
Alyson Rossa National Institutes of Health Clinical Center , Bethesda , MD , USA .
Leslie Wehrlena National Institutes of Health Clinical Center , Bethesda , MD , USA .
Stephen D Klagholza National Institutes of Health Clinical Center , Bethesda , MD , USA .
Li Yanga National Institutes of Health Clinical Center , Bethesda , MD , USA .
Richard Childsb National Heart, Lung, and Blood Institute , Bethesda , MD , USA , and.
Sharon L Flynna National Institutes of Health Clinical Center , Bethesda , MD , USA .
Alan T Remaleya National Institutes of Health Clinical Center , Bethesda , MD , USA .
Michael Krumlaufa National Institutes of Health Clinical Center , Bethesda , MD , USA .
Robert N Regerb National Heart, Lung, and Blood Institute , Bethesda , MD , USA , and.
Gwenyth R Wallena National Institutes of Health Clinical Center , Bethesda , MD , USA .
Robert Shamburekb National Heart, Lung, and Blood Institute , Bethesda , MD , USA , and.
Karel Pacakc National Institute of Child Health and Human Development , Bethesda , MD , USA.

Funding

Allogeneic Immunotherapy for cancer and nonmalignant hematological disordersZIAHL002345 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHILDS, RICHARD · 2009 to 2025
$53.3M
Physical & Emotional Health of Caregivers for People Who Had Stem Cell TransplantZIACL001154 · CLC · CLINICAL CENTER · PI BEVANS, MARGARET · 2012 to 2017
$0k
Intramural NIH HHS ZIA CL001154
6 · The paper itself

Abstract

There is growing evidence linking caregiver stress with an increased risk for morbidity and mortality. While the emotional and practical burden experienced by caregivers is well established, the physiological changes that may affect the caregiver's health are less understood. This study sought to compare self-reported stress, anxiety and depression along with neuroendocrine and immune markers of stress among adult caregivers of allogeneic hematopoietic stem cell transplantation patients during the acute transplant recovery period to matched non-caregivers controls. Biomarkers and self-reported data were collected at three points during the patient's HSCT: (1) before transplant, (2) after initial transplantation discharge (±7 days) and (3) 6 weeks after initial transplantation discharge. Mixed linear modeling was used to examine differences by group and time. Twenty-one caregivers and 20 controls completed all study procedures. The majority of caregivers were female (57% or 57.1%) and married (95.2%), with a mean age of 52 ± 11.4 years. Caregiver perceived stress, anxiety and depression scores were significantly higher than controls (p < 0.001) with effect sizes (ES) ranging from 1.37 to 1.80 and they did not change over time (p > 0.05) for either group. Caregivers had significantly lower serum cortisol levels than controls at both discharge (p = 0.013; ES = 0.81) and 6 weeks after discharge (p = 0.028; ES = 0.72) but exhibited no significant relationship between self-reported stress and serum cortisol. In addition, caregivers showed a significant inverse relationship between stress and epinephrine levels (r(s)=-0.654, p = 0.021). These findings support the evidence of the caregiving experience being stressful. The counter-intuitive relationship between cortisol and epinephrine might suggest dysregulation of the HPA axis and central nervous system but additional research on the physiological impact of caregiving is warranted.

Indexed as

AdultAnxietyCaregiversCost of IllnessDepressionEmotionsFemaleHematopoietic Stem Cell TransplantationHumansHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemStress, PsychologicalbiomarkersburdencancerCaregiverfamilypsychologicalstress responsetransplant

Identifiers

PMID26949170
PMCPMC4976925

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.