ArticleBMB reports2016
A novel IL-10-producing innate lymphoid cells (ILC10) in a contact hypersensitivity mouse model.
Article in BMB reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- IL-27-induced PD-L1Experimental & molecular medicine · 2024Article
- Vitamin DThe journal of allergy and clinical immunology. Global · 2023Article
- Stem Cell Therapy and Innate Lymphoid Cells.Stem cells international · 2022Review
- Innate Immune Mechanisms in Contact Dermatitis.Handbook of experimental pharmacology · 2022Article
- A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review).Molecular medicine reports · 2021Review
- Article
- CD1dFrontiers in immunology · 2021Article
- 1,25(OH)Scientific reports · 2020Article
- [Extended understanding of pathogenesis and treatment of contact allergy].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020Review
- A Framework of All Discovered Immunological Pathways and Their Roles for Four Specific Types of Pathogens and Hypersensitivities.Frontiers in immunology · 2020Review
- Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β.Scientific reports · 2019Article
- Context Dependent Role of Type 2 Innate Lymphoid Cells in Allergic Skin Inflammation.Frontiers in immunology · 2019Review
- Dissecting human ILC heterogeneity: more than just three subsets.Immunology · 2018Review
- JQ1, a BET inhibitor, controls TLR4-induced IL-10 production in regulatory B cells by BRD4-NF-κB axis.BMB reports · 2017Article
- Type two innate lymphoid cells: the Janus cells in health and disease.Immunological reviews · 2017Review
- Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases.Nature reviews. Rheumatology · 2017Review
- Evaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phases.Anais brasileiros de dermatologiaObservational
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immunoregulatory cytokine Interleukin 10 (IL-10) protein is produced by various cells during the course of inflammatory disorders. Mainly, it downregulates pro-inflammatory cytokines, antigen presentation, and helper T cell activation. In this study, we show that the ratio of IL-10-producing cells was significantly increased in lineage negative (i.e., not T, B, or leukocyte cell lineages) cells than in lineage positive cells in lymphoid and peripheral tissues. We further observed that IL-10-producing innate lymphoid cells (ILCs), here called firstly ILC10, were increased in number in oxazolone-induced contact hypersensitivity (CHS) mice. In detail, IL-10-producing lineage negative cells were elevated in the axillary, inguinal lymph node, and ear tissues of CHS mice. Notably, the cells expressed classical ILC marker proteins such as CD45, CD127, and Sca-1. Altogether, our findings suggest for the first time that ILC10s are present in various physiological settings and could be involved in numerous immune responses as regulatory cells. [BMB Reports 2016; 49(5): 293-296].
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