ArticleNeuron2016
A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.
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Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 1 of them a synthesis that pooled it.
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195citing papers in PubMed, 1 pooled it
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Who cites it
195 citing papers in PubMed, 1 synthesis or guideline pooled it, 389 citations in OpenAlex.
- Touching body, soul, and spirit? Understanding external applications from integrative medicine: A mixed methods systematic review.Frontiers in medicine · 2022Pooled it
- Adhesive pyramidal thorn patches provide pain relief to athletes.The Kaohsiung journal of medical sciences · 2019Trial
- Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study.Journal of translational medicine · 2019Trial
- Microbial lysate upregulates host oxytocin.Brain, behavior, and immunity · 2017Trial
- A Hypothalamic Oxytocinergic-Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon-Bone Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hypothalamic-amygdala gating of caregiving-like prosocial behavior in mice.The Journal of clinical investigation · 2026Article
- Pain Expectation in Individuals With High Autistic Traits: Decision-Evaluation Processes and Oxytocin Modulation.Annals of the New York Academy of Sciences · 2026Article
- Mapping of oxytocin- and arginine vasopressin-expressing neurons with calbindin 1 or reelin in the male mouse brain.Journal of neuroendocrinology · 2026Article
- Optical insights into spatial precision and release heterogeneity of neuromodulatory transmission.iScience · 2026Article
- Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons.Traffic (Copenhagen, Denmark) · 2026Article
- Article
- Prostaglandin signaling drives peripheral inflammation-induced reduction of hypothalamic oxytocin-positive neurons.Cellular and molecular life sciences : CMLS · 2026Article
- Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner.Neuroscience bulletin · 2026Article
- Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Spatial organization and sex differences of paraventricular hypothalamic oxytocin neurons projecting to distinct brain regions.Brain structure & function · 2026Article
- Oxytocin Modulation of Spinal Circuits Drives Therapeutic Benefits of Massage.bioRxiv : the preprint server for biology · 2026Article
- Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex.Nature communications · 2026Article
- Acute and chronic stress differentially regulate pain via distinct ensembles in the paraventricular nucleus of hypothalamus.Molecular psychiatry · 2026Article
- Transcutaneous auricular vagus nerve stimulation after cesarean delivery: current evidence and trial design priorities.Frontiers in medicine · 2026Review
- Physiological changes of cortisol and oxytocin following manual therapy: a scoping review.Frontiers in rehabilitation sciences · 2026Review
135 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors at 11 institutions in 6 countries.
Marina EliavaSchaller Research Group on Neuropeptides at German Cancer Research Center (DKFZ) and Cell Network Cluster of Excellence at the University of Heidelberg, Heidelberg 69120, Germany.
Meggane MelchiorInstitut of Cellular and Integrative Neurosciences (INCI) UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, Strasbourg 67084, France.
H Sophie Knobloch-BollmannSchaller Research Group on Neuropeptides at German Cancer Research Center (DKFZ) and Cell Network Cluster of Excellence at the University of Heidelberg, Heidelberg 69120, Germany; Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Jérôme WahisInstitut of Cellular and Integrative Neurosciences (INCI) UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, Strasbourg 67084, France.
Miriam da Silva GouveiaSchaller Research Group on Neuropeptides at German Cancer Research Center (DKFZ) and Cell Network Cluster of Excellence at the University of Heidelberg, Heidelberg 69120, Germany.
Yan TangSchaller Research Group on Neuropeptides at German Cancer Research Center (DKFZ) and Cell Network Cluster of Excellence at the University of Heidelberg, Heidelberg 69120, Germany; Institute of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
Alexandru Cristian CiobanuCenter for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne 1008, Switzerland.
Rodrigo Triana Del RioCenter for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne 1008, Switzerland.
Lena C RothSchaller Research Group on Neuropeptides at German Cancer Research Center (DKFZ) and Cell Network Cluster of Excellence at the University of Heidelberg, Heidelberg 69120, Germany; Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Ferdinand AlthammerSchaller Research Group on Neuropeptides at German Cancer Research Center (DKFZ) and Cell Network Cluster of Excellence at the University of Heidelberg, Heidelberg 69120, Germany.
Virginie ChavantInstitut of Cellular and Integrative Neurosciences (INCI) UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, Strasbourg 67084, France.
Yannick GoumonInstitut of Cellular and Integrative Neurosciences (INCI) UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, Strasbourg 67084, France.
Tim GruberSchaller Research Group on Neuropeptides at German Cancer Research Center (DKFZ) and Cell Network Cluster of Excellence at the University of Heidelberg, Heidelberg 69120, Germany; Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Nathalie Petit-DemoulièreInstitut of Cellular and Integrative Neurosciences (INCI) UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, Strasbourg 67084, France.
Marta BusnelliNational Research Council, Institute of Neuroscience, Milan 20129, Italy.
Bice ChiniNational Research Council, Institute of Neuroscience, Milan 20129, Italy; Humanitas Clinical and Research Center, Rozzano 20089, Italy.
Linette L TanDepartment for Molecular Pharmacology and Molecular Medicine Partnership Unit with European Molecular Biology Laboratories, Institute of Pharmacology, Heidelberg University, Heidelberg 69120, Germany.
Mariela MitreSkirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Robert C FroemkeSkirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Moses V ChaoSkirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Günter GieseMax Planck Institute for Medical Research, Heidelberg 69120, Germany.
Rolf SprengelMax Planck Institute for Medical Research, Heidelberg 69120, Germany.
Rohini KunerDepartment for Molecular Pharmacology and Molecular Medicine Partnership Unit with European Molecular Biology Laboratories, Institute of Pharmacology, Heidelberg University, Heidelberg 69120, Germany.
Pierrick PoisbeauInstitut of Cellular and Integrative Neurosciences (INCI) UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, Strasbourg 67084, France.
Peter H SeeburgMax Planck Institute for Medical Research, Heidelberg 69120, Germany.
Ron StoopCenter for Psychiatric Neurosciences, Hôpital de Cery, Lausanne University Hospital (CHUV), Lausanne 1008, Switzerland.
Alexandre CharletInstitut of Cellular and Integrative Neurosciences (INCI) UPR3212, Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, Strasbourg 67084, France; University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg 67000, France. Electronic address: acharlet@unistra.fr.
Valery GrinevichSchaller Research Group on Neuropeptides at German Cancer Research Center (DKFZ) and Cell Network Cluster of Excellence at the University of Heidelberg, Heidelberg 69120, Germany; Max Planck Institute for Medical Research, Heidelberg 69120, Germany; Central Institute of Mental Health (ZI), Mannheim 68159, Germany. Electronic address: v.grinevich@dkfz-heidelberg.de.
Heidelberg University · DEInstitut des Neurosciences Cellulaires et Intégratives · FRGerman Cancer Research Center · DEMax Planck Institute for Medical Research · DEUniversity Hospital of Lausanne · CHNYU Langone Health · USEast China Normal University · CNHumanitas University · ITNational Research Council · ITNew York University · USUniversité de Strasbourg · FR
Funding
MEDICAL SCIENTIST TRAININGT32GM007308 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 1985 to 2019
$23.2MSynaptic basis of perceptual learning with cochlear implants in rat auditory cortex - RenewalR01DC012557 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Robert Crooks Froemke, Mario A Svirsky · 2013 to 2026
$7.0MTraining Program in Molecular, Cellular, and Translational NeuroscienceT32NS086750 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JEREMY S DASEN, Katherine Nagel · 2014 to 2026
$2.4MNIDCD NIH HHS R01 DC012557NIGMS NIH HHS T32 GM007308NINDS NIH HHS T32 NS086750
Abstract
Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT neurons of these nuclei innervate numerous forebrain regions and release OT into the blood from the posterior pituitary. The PVN also harbors parvocellular OT cells that project to the brainstem and spinal cord, but their function has not been directly assessed. Here, we identified a subset of approximately 30 parvocellular OT neurons, with collateral projections onto magnocellular OT neurons and neurons of deep layers of the spinal cord. Evoked OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of inflammatory pain. Our findings identify a new population of OT neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhibiting their activity and (2) indirectly by stimulating OT release from SON neurons into the periphery.
Indexed as
Action PotentialsAnimalsCholecystokininDisease Models, AnimalExcitatory Amino Acid AntagonistsGene Expression RegulationInflammationNeuralgiaNeural PathwaysNeuronsOxytocinParaventricular Hypothalamic NucleusQuinoxalinesRatsRats, WistarReceptors, Oxytocin2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxalineCholecystokininExcitatory Amino Acid AntagonistsOxytocinQuinoxalinesReceptors, OxytocinSlc17a6 protein, ratVasopressinsVesicular Glutamate Transport Protein 2
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