Evidence map›Paper›PMID 26948834›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2016

Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment.

Anitha Vijayan, Sarah Faubel, David J Askenazi, Jorge Cerda, William H Fissell, Michael Heung, Benjamin D Humphreys, Jay L Koyner, Kathleen D Liu, Girish Mour and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06291714 (Prospective Interventional Study Investigating a Goal-directed Therapy Based on Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Hypotension in Patients Undergoing Major Orthopedic and Trauma Surgery), which is not on this map. Cited by 118 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06291714 narecruitingnot on this mapstarted 2024, after this paper: background citation

Prospective Interventional Study Investigating a Goal-directed Therapy Based on Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Hypotension in Patients Undergoing Major Orthopedic and Trauma Surgery

TypeinterventionalSponsorUniversity of GiessenRan2024 to 2026Enrolled150ConditionsIntraoperative Hypotension, Acute Kidney Injury, Myocardial Injury After Non-cardiac SurgeryArmsGDT-based hemodynamic management based on Clearsight device
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  17. Water intake mediates cross-sectional associations between urinary kidney injury biomarkers and race in emerging adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anitha VijayanRenal Division, Department of Medicine, Washington University in St. Louis, St. Louis, MO. Electronic address: avijayan@dom.wustl.edu.
Sarah FaubelRenal Division, University of Colorado Denver and Denver VA Medical Center, Denver, CO.
David J AskenaziDivision of Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, AL.
Jorge CerdaAlbany Medical College, Albany, NY.
William H FissellDivision of Nephrology, Department of Medicine, Vanderbilt University, Nashville, TN.
Michael HeungDivision of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI.
Benjamin D HumphreysRenal Division, Department of Medicine, Washington University in St. Louis, St. Louis, MO.
Jay L KoynerSection of Nephrology, Department of Medicine, University of Chicago, Chicago, IL.
Kathleen D LiuDepartment of Medicine, University of California, San Francisco, San Francisco, CA; Department of Anesthesia, University of California, San Francisco, San Francisco, CA.
Girish MourRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
Thomas D NolinDepartment of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA.
Azra BihoracDepartment of Medicine, University of Florida, Gainesville, FL; Department of Anesthesiology, University of Florida, Gainesville, FL; Department of Surgery, University of Florida, Gainesville, FL.
American Society of Nephrology Acute Kidney Injury Advisory Group

Funding

PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7M
Integrating data, algorithms and clinical reasoning for surgical risk assessmentR01GM110240 · NIGMS · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2016 to 2025
$5.1M
"Validation of Novel CKD Biomarkers in CRIC"U01DK085649 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN, LIU, KATHLEEN D · 2009 to 2013
$4.4M
Novel Human Biomarkers of Kidney FibrosisU01DK104308 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HUMPHREYS, BENJAMIN D., WAIKAR, SUSHRUT S. · 2014 to 2018
$2.0M
NIDDK NIH HHS U01 DK085649NIDDK NIH HHS U01 DK104308NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM110240
6 · The paper itself

Abstract

Acute kidney injury (AKI) is a serious complication, commonly occurring in the critically ill population, with devastating short- and long-term consequences. Despite standardization of the definition and staging of AKI, early recognition remains challenging given that serum creatinine level is a marker, albeit imperfect, of kidney function and not kidney injury. Furthermore, the delay in increase in serum creatinine level after loss of glomerular filtration also prevents timely detection of decreased kidney function in patients with AKI. During the past decade, numerous clinical investigations have evaluated the utility of several biomarkers in the early diagnosis and risk stratification of AKI. In 2014, the US Food and Drug Administration approved the marketing of a test based on the combination of urine concentrations of tissue inhibitor of metalloproteinase 2 and insulin-like growth factor binding protein 7 ([TIMP-2] × [IGFBP7]) to determine whether certain critically ill patients are at risk for developing moderate to severe AKI. The optimal role of this biomarker in the diagnosis, management, and prognosis of AKI in different clinical settings requires further clarification. In this perspective, we summarize the biological actions of these 2 cell-cycle arrest biomarkers and present important considerations regarding the clinical application, interpretation, and limitations of this novel test for the early detection of AKI.

Indexed as

Acute Kidney InjuryBiomarkersClinical Trials as TopicDecision TreesEarly DiagnosisHumansInsulin-Like Growth Factor Binding ProteinsRisk AssessmentTissue Inhibitor of Metalloproteinase-2Biomarkersinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2Acute kidney injury (AKI)biomarkercritically illdecreased kidney functiondiagnosisearly detectioninsulin-like growth factor binding protein 7NephroCheckrenal dysfunctionrisk assessment[TIMP-2] × [IGFBP7]tissue inhibitor of metalloproteinase 2

Identifiers

PMID26948834
PMCPMC4921267

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.