ArticleJournal of cataract and refractive surgery2016
Comparison of very-high-frequency ultrasound and spectral-domain optical coherence tomography corneal and epithelial thickness maps.
Article in Journal of cataract and refractive surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01403129 (Early Detection of Keratoconus Using Ultrasound), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Keratoconus Using Ultrasound
Who cites it
7 citing papers in PubMed, 29 citations in OpenAlex.
- Determining the Relationship Between Regional Epithelial Thickness, Corneal Toricity, and Corneal Power in Normal Corneas.Journal of refractive surgery (Thorofare, N.J. : 1995) · 2025Article
- Inter-zonal epithelial thickness differences for early keratoconus detection using optical coherence tomography.Eye (London, England) · 2024Article
- Clinical Applications of Anterior Segment Optical Coherence Tomography: An Updated Review.Diagnostics (Basel, Switzerland) · 2024Review
- Corneal Epithelial Thickness Mapping: A Major Review.Journal of ophthalmology · 2024Review
- Corneal Epithelial Mapping Characteristics in Normal Eyes Using Anterior Segment Spectral Domain Optical Coherence Tomography.Translational vision science & technology · 2022Article
- Improved High-Frequency Ultrasound Corneal Biometric Accuracy by Micrometer-Resolution Acoustic-Property Maps of the Cornea.Translational vision science & technology · 2018Article
- Understanding Corneal Epithelial Thickness Mapping.Middle East African journal of ophthalmologyReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo compare corneal thickness and epithelial thickness measurements in maps obtained using the RTVue spectral domain optical coherence tomography (SD-OCT) system and the Artemis 2 immersion arc-scanning very-high-frequency ultrasound (VHF-US) system.
settingDepartment of Ophthalmology, Columbia University Medical Center, New York, New York, USA.
designComparative study.
methodsEyes of normal volunteers were scanned with the SD-OCT system followed by the VHF-US system and then again by the SD-OCT system. On each map, the minimum corneal thickness and mean values of corneal thickness and epithelial thickness in the 3.0 mm radius zone and in 0.5 mm wide concentric annuli of up to a 3.0 mm radius around the corneal vertex were determined.
resultsBoth eyes of 12 normal volunteers were scanned. The corneal thickness values from both devices were highly correlated (R > 0.96); in the 3.0 mm radius zone, they were not statistically significantly different. There was no statistically significant change in epithelial thickness or corneal thickness in SD-OCT measurements taken before versus after immersion US. Although highly correlated (R > 0.76), the SD-OCT epithelial thickness values were systematically thinner (1.7 ± 2.1 μm) than the VHF-US measurements in the 3.0 mm radius zone (P < .01).
conclusionsThe corneal thickness measurements in the 3.0 mm radius zone in normal eyes were equivalent between the 2 systems. Although correlated, the VHF-US epithelial thickness measurements were systemically thicker than the SD-OCT values. FINANCIAL DISCLOSURES: Drs. Silverman and Reinstein have a commercial interest in Arcscan, Inc. Dr. Reinstein is a consultant to Carl Zeiss Meditec. None of the other authors has a financial or proprietary interest in any material or method presented.
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Registered trials
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