ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2016
Metacognitive impairment in active cocaine use disorder is associated with individual differences in brain structure.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Metacognitive sensitivity and symptoms of mental disorder: A systematic review and meta-analysis.Frontiers in psychology · 2023Pooled it
- The Impaired Response Inhibition and Salience Attribution Model of Drug Addiction: Recent Neuroimaging Evidence and Future Directions.Annual review of psychology · 2026Review
- Computational characterization of metacognitive ability in subjective decision-making.bioRxiv : the preprint server for biology · 2025Article
- Neural Correlates of Metacognition Impairment in Opioid Addiction.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- The Mental Suffering of Cocaine-Addicted Patients: A Retrospective Analysis of Personality Disorders' Prevalence and Their Association with Psychopathological Symptoms.European journal of investigation in health, psychology and education · 2024Article
- Modeling impaired insight after drug use in rodents.Behavioral neuroscience · 2024Review
- Hot metacognition: poorer metacognitive efficiency following acute but not traumatic stress.Translational psychiatry · 2024Article
- Observational
- Recreational drug use and prospective memory.Psychopharmacology · 2022Article
- The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Neural and Behavioral Correlates of Impaired Insight and Self-Awareness in Substance Use Disorder.Current behavioral neuroscience reports · 2021Article
- Frontopolar theta oscillations link metacognition with prospective decision making.Nature communications · 2021Article
- The Metacognitive Processes of Decentering Scale: Development and initial validation of trait and state versions.Psychological assessment · 2020Article
- Self-awareness of problematic drug use: Preliminary validation of a new fMRI task to assess underlying neurocircuitry.Drug and alcohol dependence · 2020Article
- Behavioral preference for viewing drugPsychological medicine · 2020Article
- Abnormalities of confidence in psychiatry: an overview and future perspectives.Translational psychiatry · 2019Review
- Explicit and implicit monitoring in neurodegeneration and stroke.Scientific reports · 2019Article
- Let's Open the Decision-Making Umbrella: A Framework for Conceptualizing and Assessing Features of Impaired Decision Making in Addiction.Neuropsychology review · 2019Review
- Cognitive impairment in substance use disorders.CNS spectrums · 2019Article
- The importance of considering polysubstance use: lessons from cocaine research.Drug and alcohol dependence · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Dysfunctional self-awareness has been posited as a key feature of drug addiction, contributing to compromised control over addictive behaviors. In the present investigation, we showed that, compared with healthy controls (n=13) and even individuals with remitted cocaine use disorder (n=14), individuals with active cocaine use disorder (n=8) exhibited deficits in basic metacognition, defined as a weaker link between objective performance and self-reported confidence of performance on a visuo-perceptual accuracy task. This metacognitive deficit was accompanied by gray matter volume decreases, also most pronounced in individuals with active cocaine use disorder, in the rostral anterior cingulate cortex, a region necessary for this function in health. Our results thus provide a direct unbiased measurement - not relying on long-term memory or multifaceted choice behavior - of metacognition deficits in drug addiction, which are further mapped onto structural deficits in a brain region that subserves metacognitive accuracy in health and self-awareness in drug addiction. Impairments of metacognition could provide a basic mechanism underlying the higher-order self-awareness deficits in addiction, particularly among recent, active users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.