ArticleLife sciences in space research2016
A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation.
Article in Life sciences in space research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025Pooled it
- Effects of Proton Therapy on Cardiac Fibrosis, Calcium Homeostasis, and AQP4 Expression in Hypergravity-Exposed Rats.International journal of molecular sciences · 2025Article
- Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading.Life sciences in space research · 2025Article
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model.Life sciences in space research · 2023Article
- Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart.Life (Basel, Switzerland) · 2023Article
- Lifetime evaluation of left ventricular structure and function in male ApoE null mice after gamma and space-type radiation exposure.Frontiers in physiology · 2023Article
- Is space flight arrhythmogenic?Frontiers in physiology · 2023Article
- Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice.Life sciences in space research · 2022Article
- Biological Protection in Deep Space Missions.Journal of biomedical physics & engineering · 2021Review
- Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model.Life sciences in space research · 2021Article
- Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem.Frontiers in cardiovascular medicine · 2021Review
- MicroRNAs Responding to Space Radiation.International journal of molecular sciences · 2020Review
- Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats.Life sciences in space research · 2020Article
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (Life sciences in space research · 2019Article
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice.Life sciences in space research · 2019Article
- Radiation-Induced Cardiovascular Disease: Mechanisms and Importance of Linear Energy Transfer.Frontiers in cardiovascular medicine · 2018Review
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- Interplay of space radiation and microgravity in DNA damage and DNA damage response.NPJ microgravity · 2017Article
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.Environmental research · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeRecent evidence suggests that the heart may be injured by ionizing radiation at lower doses than was previously thought. This raises concerns about the cardiovascular risks from exposure to radiation during space travel. Since space travel is associated with exposure to both protons from solar particle events and heavy ions from galactic cosmic rays, we here examined the effects of a "priming" dose of protons on the cardiac cellular and molecular response to a "challenge" dose of (56)Fe in a mouse model.
methodsMale C57BL/6 mice at 10 weeks of age were exposed to sham-irradiation, 0.1 Gy of protons (150 MeV), 0.5 Gy of (56)Fe (600 MeV/n), or 0.1 Gy of protons 24 hours prior to 0.5 Gy of (56)Fe. Hearts were obtained at 7 days post-irradiation and western-blots were used to determine protein markers of cardiac remodeling, inflammatory infiltration, and cell death.
resultsExposure to (56)Fe caused an increase in expression of α-smooth muscle cell actin, collagen type III, the inflammatory cell markers mast cell tryptase, CD2 and CD68, the endothelial glycoprotein thrombomodulin, and cleaved caspase 3. Of all proteins investigated, protons at a dose of 0.1 Gy induced a small increase only in cleaved caspase 3 levels. On the other hand, exposure to protons 24 hours before (56)Fe prevented all of the responses to (56)Fe.
conclusionsThis study shows that a low dose of protons may prime the heart to respond differently to a subsequent challenge dose of heavy ions. Further investigation is required to identify responses at additional time points, consequences for cardiac function, threshold dose levels, and mechanisms by which a proton priming dose may alter the response to heavy ions.
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Registered trials
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