ReviewThe Journal of allergy and clinical immunology2016
The contributions of allergic sensitization and respiratory pathogens to asthma inception.
Review in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease.Nature communications · 2025Article
- Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children.American journal of human genetics · 2025Article
- Contributions of the early-life microbiome to childhood atopy and asthma development.Seminars in immunology · 2023Review
- A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.The Journal of allergy and clinical immunology · 2023Article
- Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm.Journal of personalized medicine · 2022Review
- Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation.Clinical and translational medicine · 2021Article
- Review
- Determinants of Allergic Sensitization, Asthma and Lung Function: Results from a Cross-Sectional Study in Italian Schoolchildren.International journal of environmental research and public health · 2020Article
- Prenatal pesticide exposure and respiratory health outcomes in the first year of life: Results from the infants' Environmental Health (ISA) study.International journal of hygiene and environmental health · 2020Article
- The Respiratory Mucosa: Front and Center in Respiratory Syncytial Virus Disease.American journal of respiratory and critical care medicine · 2019Article
- Asthma and viral infections: An intricate relationship.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Review
- Asthma exacerbation related to viral infections: An up to date summary.Journal of family medicine and primary care · 2019Article
- Early Airway Pathological Changes in Children: New Insights into the Natural History of Wheezing.Journal of clinical medicine · 2019Review
- Early life ovalbumin sensitization and aerosol challenge for the induction ofallergic airway inflammation in a BALB/c murine model.Bio-protocol · 2019Article
- Heterogeneity and the origins of asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Review
- TThe Journal of allergy and clinical immunology · 2018Article
- Timing of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study.The Journal of infectious diseases · 2018Article
- Pathogenic CD4The Journal of allergy and clinical immunology · 2017Review
- Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future.ILAR journal · 2017Review
- Rhinovirus-induced first wheezing episode predicts atopic but not nonatopic asthma at school age.The Journal of allergy and clinical immunology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Of the chronic diseases affecting grade-school children, asthma is the most common and accounts for the greatest number of school days missed. Moreover, it can influence family dynamics and function in other ways, and unfortunately, it can also be associated with mortality, particularly in the inner-city environments of the United States. Thus understanding factors that lead to its development in early life is essential in developing strategies aimed at primary prevention. Two risk factors that have been identified by a number of investigators include the development of allergic sensitization and wheezing respiratory tract illnesses caused by viruses and bacteria, either alone or in combination. Both of these factors appear to exert their influences within the first few years of life, such that asthma becomes established before the child enters grade school at age 5 to 6 years. Therefore, because both allergic sensitization and viral and bacterial illnesses can occur in children who do not have asthma, it is paramount to identify genetic and environmental factors that activate, interact with, and/or direct the immune system and components of the respiratory tract along pathways that allow asthma to become established and expressed clinically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.