Trial reportThe Journal of pediatrics2016
A Randomized Controlled Trial of an Outpatient Protocol for Transitioning Children from Tube to Oral Feeding: No Need for Amitriptyline.
Trial report in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01206478 (A Phase II, Randomized-Controlled, Multicenter Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase II, Randomized-Controlled, Multicenter Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pediatric Tube Weaning: A Meta-Analysis of Factors Contributing to Success.Journal of clinical psychology in medical settings · 2023Pooled it
- Rome V Pediatric Upper Gastrointestinal Disorders of Gut-Brain Interaction.Gastroenterology · 2026Review
- Enhancing Pediatric Tube Weaning with Remote Patient Monitoring: A Pilot Quasi-Experimental Study.Nutrients · 2026Article
- Reduction in Feeding Problems and Impact on Family Following a 12-Week Interdisciplinary Group Feeding Intervention for Children With Feeding Problems and Their Caregivers.Cognitive and behavioral practice · 2025Article
- Effectiveness of nurse-led combined modalities on the physiological parameters of preterm neonates admitted to neonatal intensive care units at a selected tertiary care hospital.Journal of education and health promotion · 2025Article
- Behavior Analytic Feeding Interventions: Current State of the Literature.Behavior modification · 2023Review
- Evaluating Outcome Measure Data for an Intensive Interdisciplinary Home-Based Pediatric Feeding Disorders Program.Nutrients · 2022Article
- Weaning children from prolonged enteral nutrition: A position paper.European journal of clinical nutrition · 2022Article
- Family mealtime behaviors in children who are tube fed and preparing to transition to oral eating: A comparison to other pediatric populations.Journal of health psychology · 2022Article
- iKanEat: protocol for a randomized controlled trial of megestrol as a component of a pediatric tube weaning protocol.Trials · 2021Article
- Botulinum Toxin as a Treatment for Feeding Difficulties in Young Children.The Journal of pediatrics · 2020Article
- Impact of a pre-feeding oral stimulation program on first feed attempt in preterm infants: Double-blind controlled clinical trial.PloS one · 2020Article
- Health related quality of life of infants and children with avoidant restrictive food intake disorder.The International journal of eating disorders · 2019Article
- Psychometrics of the Functional Oral Intake Scale for Infants.Frontiers in pediatrics · 2019Article
- Development, prevention, and treatment of feeding tube dependency.European journal of pediatrics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveTo assess the role of amitriptyline in the effectiveness of an outpatient protocol for weaning medically complicated children from tube to oral feeding. STUDY
designTwenty-one children seen in multidisciplinary outpatient feeding teams across 4 sites were recruited to a randomized placebo-controlled trial of a 6-month outpatient treatment protocol with behavioral, oral-motor, nutrition, and medication components.
resultsAll of the children who completed the 6-month program (73%) were weaned to receive only oral feeding, regardless of group assignment. The transition from tube to oral feeding resulted in decreases in body mass index percentile and pain, some improvements in quality of life, and no statistically significant changes in cost.
conclusionsAmitriptyline is not a key component of this otherwise effective outpatient, interdisciplinary protocol for weaning children from tube to oral feeding.
trial registrationClinicalTrials.gov: NCT01206478.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.