ArticleEcotoxicology (London, England)2016
ace-3 plays an important role in phoxim resistance in Caenorhabditis elegans.
Article in Ecotoxicology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Transcriptional changes of biochemical pathways in Meloidogyne incognita in response to non-fumigant nematicides.Scientific reports · 2022Article
- The ACE genes in Aphelenchoides besseyi isolates and their expression correlation to the fenamiphos treatment.Scientific reports · 2022Article
- Article
- Potential attenuation of biochemical parameters and enzymatic functions in Cyprinus carpio fingerlings by Phenthoate 50 EC insecticide exposure.Environmental science and pollution research international · 2020Article
- Protective role of citric acid against oxidative stress induced by heavy metals in Caenorhabditis elegans.Environmental science and pollution research international · 2019Article
- Evaluation of the StrainMolecules (Basel, Switzerland) · 2019Article
- Two Bombyx mori acetylcholinesterase genes influence motor control and development in different ways.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Organophosphorus and carbamate are widely used in agricultural production. Caenorhabditis elegans is a model organism that is widely used in various toxicology studies. To understand the effects of two types of commonly used pesticides, phoxim (organophosphorus) and carbaryl (carbamate), we determined the activities of acetylcholinesterases (AChEs) and detected the expression of four ace genes by RT-qPCR in C. elegans following treatment with these pesticides. The results showed that phoxim and carbaryl could reduce acetylcholinesterase activities and up-regulate the ace-3 mRNA expression levels. We also detected the toxic effects of these pesticides on the ace-3 deletion mutant dc-2, and found that some characteristics, including LC50, development, movement, reproduction and lifespan, were reduced in the dc-2 mutant. However, the toxic effects of carbaryl were weaker than those of phoxim. Carbaryl treatment did not significantly affect the LC50, movement ability or lifespan. Interestingly, body and brood size increased with carbaryl treatment at low concentrations. These data showed that both phoxim and carbaryl could inhibit AChE but that the ace-3 was necessary for phoxim detoxification. The LC50 of phoxim and carbaryl in wild type N2 and the ace-3 deletion mutant dc-2. **Higher significant differences (P < 0.01).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.