Evidence map›Paper›PMID 26947162›Full record

ArticleJournal of chromatography. A2016

Chromatographic separation of germanium and arsenic for the production of high purity (77)As.

Matthew D Gott, Anthony J DeGraffenreid, Yutian Feng, Michael D Phipps, Donald E Wycoff, Mary F Embree, Cathy S Cutler, Alan R Ketring, Silvia S Jurisson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chromatography. A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 23 citations in OpenAlex.

  1. PET radiometals for antibody labeling.Journal of labelled compounds & radiopharmaceuticals · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Matthew D GottDepartment of Chemistry, University of Missouri, Columbia, MO 65211, United States.
Anthony J DeGraffenreidDepartment of Chemistry, University of Missouri, Columbia, MO 65211, United States.
Yutian FengDepartment of Chemistry, University of Missouri, Columbia, MO 65211, United States.
Michael D PhippsDepartment of Chemistry, University of Missouri, Columbia, MO 65211, United States.
Donald E WycoffDepartment of Chemistry, University of Missouri, Columbia, MO 65211, United States.
Mary F EmbreeUniversity of Missouri Research Reactor Center, Columbia, MO 65211, United States.
Cathy S CutlerUniversity of Missouri Research Reactor Center, Columbia, MO 65211, United States.
Alan R KetringUniversity of Missouri Research Reactor Center, Columbia, MO 65211, United States.
Silvia S JurissonDepartment of Chemistry, University of Missouri, Columbia, MO 65211, United States. Electronic address: jurissons@missouri.edu.
University of Missouri · US

Funding

Graduate Training in Radiopharmaceutical ChemistryT32EB004822 · NIBIB · UNIVERSITY OF MISSOURI-COLUMBIA · PI JURISSON, SILVIA S. · 2007 to 2011
$744k
NIBIB NIH HHS 5 T32-EB004822NIBIB NIH HHS T32 EB004822
6 · The paper itself

Abstract

A simple column chromatographic method was developed to isolate (77)As (94±6% (EtOH/HCl); 74±11 (MeOH)) from germanium for potential use in radioimmunotherapy. The separation of arsenic from germanium was based on their relative affinities for different chromatographic materials in aqueous and organic environments. Using an organic or mixed mobile phase, germanium was selectively retained on a silica gel column as germanate, while arsenic was eluted from the column as arsenate. Subsequently, enriched (76)Ge (98±2) was recovered for reuse by elution with aqueous solution (neutral to basic). Greater than 98% radiolabeling yield of a (77)As-trithiol was observed from methanol separated [(77)As]arsenate [17].

Indexed as

ArsenicChromatography, LiquidGermaniumMethanolRadioisotopesSilica GelSolventsWaterArsenicGermaniumMethanolRadioisotopesSilica GelSolventsWaterColumn chromatographyGe/As distribution coefficientGe/As separationHigh specific activity arsenic-77

Identifiers

PMID26947162
PMCPMC4803594
OpenAlexW2290463471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.