ArticleJournal of vascular surgery. Venous and lymphatic disorders2016
Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression.
Article in Journal of vascular surgery. Venous and lymphatic disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Review of adjustable velcro wrap devices for venous ulceration.International wound journal · 2019Pooled it
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- Lymphoscintigraphy is frequently recommended but seldom used in a "real world setting".Journal of vascular surgery. Venous and lymphatic disorders · 2024Article
- Case Report: The effect of automated manual lymphatic drainage therapy on lymphatic contractility in 4 distinct cases.Frontiers in medical technology · 2024Article
- Imaging peripheral lymphatic dysfunction in chronic conditions.Frontiers in physiology · 2023Review
- Lymphatic function and anatomy in early stages of lipedema.Obesity (Silver Spring, Md.) · 2022Article
- Article
- Exploring disease interrelationships in patients with lymphatic disorders: A single center retrospective experience.Clinical and translational medicine · 2022Article
- Host-guest interactions of indocyanine green with β-cyclodextrin permit real-time characterization of the rat lymphatic system.JVS-vascular science · 2022Article
- Degradation of lymphatic anatomy and function in early venous insufficiency.Journal of vascular surgery. Venous and lymphatic disorders · 2021Observational
- The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors.Cancers · 2020Review
- Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis.Nature reviews. Rheumatology · 2018Review
- Near-infrared fluorescence lymphatic imaging of Klippel-Trénaunay syndrome.Journal of vascular surgery. Venous and lymphatic disorders · 2017Article
- Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis.Arthritis research & therapy · 2017Article
- New diagnostic modalities in the evaluation of lymphedema.Journal of vascular surgery. Venous and lymphatic disorders · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundRecent advancements in near-infrared fluorescence lymphatic imaging (NIRFLI) technology provide opportunities for non-invasive, real-time assessment of lymphatic contribution in the etiology and treatment of ulcers. The objective of this study was to assess lymphatics in subjects with venous leg ulcers using NIRFLI and to assess lymphatic impact of a single session of sequential pneumatic compression (SPC).
methodsFollowing intradermal microdoses of indocyanine green (ICG) as a lymphatic contrast agent, NIRFLI was used in a pilot study to image the lymphatics of 12 subjects with active venous leg ulcers (Clinical, Etiologic, Anatomic, and Pathophysiologic [CEAP] C6). The lymphatics were imaged before and after a single session of SPC to assess impact on lymphatic function.
resultsBaseline imaging showed impaired lymphatic function and bilateral dermal backflow in all subjects with chronic venous insufficiency, even those without ulcer formation in the contralateral limb (C0 and C4 disease). SPC therapy caused proximal movement of ICG away from the active wound in 9 of 12 subjects, as indicated by newly recruited functional lymphatic vessels, emptying of distal lymphatic vessels, or proximal movement of extravascular fluid. Subjects with the longest duration of active ulcers had few visible lymphatic vessels, and proximal movement of ICG was not detected after SPC therapy.
conclusionsThis study provides visible confirmation of lymphatic dysfunction at an early stage in the etiology of venous ulcer formation and demonstrates the potential therapeutic mechanism of SPC therapy in removing excess fluid. The ability of SPC therapy to restore fluid balance through proximal movement of lymph and interstitial fluid may explain its value in hastening venous ulcer healing. Anatomical differences between the lymphatics of longstanding and more recent venous ulcers may have important therapeutic implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.