ArticleGastroenterology2016
No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.
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Article in Gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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33citing papers in PubMed, 1 pooled it
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Scale and Scope of Gene-Alcohol Interactions in Chronic Pancreatitis: A Systematic Review.Genes · 2021Pooled it
- Mutations in the pancreatic secretory enzymesProceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Assessing the effect of bovine MSTN variants on pre-mRNA splicing.Animal genetics · 2026Article
- Advancing Gene Therapy for Pancreatitis: From Genetic Insights to Clinical Translation.Research (Washington, D.C.) · 2026Review
- High-fat diet accelerates pancreas pathology in theFrontiers in physiology · 2026Article
- Carboxyl ester lipase hybrid 1 (CEL-HYB1) haplotypes confer varying risk for chronic pancreatitis.Scientific reports · 2024Article
- Alu insertion-mediated dsRNA structure formation with pre-existing Alu elements as a disease-causing mechanism.American journal of human genetics · 2024Article
- SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2024Article
- Characterization of novel PNLIP variants in congenital pancreatic lipase deficiency.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023Article
- The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022Article
- Endoplasmic stress-inducing variants in carboxyl ester lipase and pancreatic cancer risk.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022Article
- The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in Mice.Cellular and molecular gastroenterology and hepatology · 2022Article
- Prevalence and Risk Factors for Osteopathy in Chronic Pancreatitis.Digestive diseases and sciences · 2021Article
- Defining the endoscopic ultrasound features of chronic pancreatitis in Asians: a multicenter validation study.Endoscopy · 2021Article
- Review
- Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding.Human mutation · 2020Article
- Chronic Pancreatitis: Managing a Difficult Disease.The American journal of gastroenterology · 2020Review
- Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.The American journal of gastroenterology · 2019Article
- Genetics, Cell Biology, and Pathophysiology of Pancreatitis.Gastroenterology · 2019Review
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Authors and funding
26 authors at 7 institutions in 6 countries.
Wen-Bin ZouDepartment of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France; Shanghai Institute of Pancreatic Diseases, Shanghai, China.
Arnaud BoullingInstitut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale (UBO), Brest, France.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Prachand IssarapuGenomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.
Emmanuelle MassonInstitut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Universitaire (CHU) Brest, Hôpital Morvan, Brest, France.
Hao WuDepartment of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China.
Xiao-Tian SunDepartment of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China.
Liang-Hao HuDepartment of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China.
Dai-Zhan ZhouKey Laboratory of Developmental Genetics and Neuropsychiatric Diseases (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Lin HeKey Laboratory of Developmental Genetics and Neuropsychiatric Diseases (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Yann FichouInstitut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France.
Eriko NakanoDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shin HamadaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yoichi KakutaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kiyoshi KumeDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hiroyuki IsayamaDepartment of Gastroenterology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Sumit PaliwalGenomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.
K Radha ManiGenomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.
Seema BhaskarGenomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.
David N CooperInstitute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Claude FérecInstitut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale (UBO), Brest, France; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Universitaire (CHU) Brest, Hôpital Morvan, Brest, France.
Tooru ShimosegawaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Giriraj R ChandakGenomic Research on Complex Diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India; Human Genetics Division, Genome Institute of Singapore, Biopolis, Singapore; Laboratory of Human and Medical Genetics, Centre for DNA Fingerprinting & Diagnostics (CDFD), Hyderabad, India.
Jian-Min ChenInstitut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Etablissement Français du Sang (EFS)-Bretagne, Brest, France; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale (UBO), Brest, France. Electronic address: Jian-Min.Chen@univ-brest.fr.
Zhao-Shen LiDepartment of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China. Electronic address: zhaoshenli@hotmail.com.
Zhuan LiaoDepartment of Gastroenterology, Changhai Hospital, the Second Military Medical University, Shanghai, China; Shanghai Institute of Pancreatic Diseases, Shanghai, China. Electronic address: liaozhuan@smmu.edu.cn.
Inserm · FRTohoku University · JPCentre for Cellular and Molecular Biology · INSecond Military Medical University · CNShanghai Jiao Tong University · CNCardiff University · GBThe University of Tokyo · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
A hybrid allele between the carboxyl ester lipase gene (CEL) and its pseudogene, CELP (called CEL-HYB), generated by nonallelic homologous recombination between CEL intron 10 and CELP intron 10', was found to increase susceptibility to chronic pancreatitis in a case-control study of patients of European ancestry. We attempted to replicate this finding in 3 independent cohorts from China, Japan, and India, but failed to detect the CEL-HYB allele in any of these populations. The CEL-HYB allele might therefore be an ethnic-specific risk factor for chronic pancreatitis. An alternative hybrid allele (CEL-HYB2) was identified in all 3 Asian populations (1.7% combined carrier frequency), but was not associated with chronic pancreatitis.
Indexed as
Genetic Predisposition to DiseaseAllelesAsian PeopleCase-Control StudiesChinaHumansIndiaInteinsJapanLipasePancreatitis, ChronicPseudogenesWhite PeopleCEL protein, humanLipaseDisease SusceptibilityHuman GeneticsNonsense-Mediated mRNA DecayPancreatic Acinar Cells
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