ArticleJournal of magnetic resonance imaging : JMRI2016
Native myocardial longitudinal (T1 ) relaxation time: Regional, age, and sex associations in the healthy adult heart.
Article in Journal of magnetic resonance imaging : JMRI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Society for Cardiovascular Magnetic Resonance reference values ("normal values") in cardiovascular magnetic resonance: 2025 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Guideline
- Diastolic echocardiographic parameters identify pediatric kidney transplant recipients with structural myocardial alterations.Pediatric nephrology (Berlin, Germany) · 2026Article
- Native myocardial T1 reference values in a tunisian cohort using MOLLI and SMART1Map.Scientific reports · 2026Article
- Age-, sex-, and segment-specific myocardial T1 and T2 reference values in a healthy cohort: a prospective single-center study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Reference ranges for myocardial native T1, T2, and extracellular volume at 5.0T cardiac magnetic resonance imaging in healthy adults.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026Article
- Rotating Frame Relaxation Time Mapping for the Visualization of the Sinoatrial Node Without Contrast Agent.NMR in biomedicine · 2025Article
- Advancing Myocardial T1 Mapping: A Comparative Study of the Frequency-Independent MFA Sequence and Standard MOLLI.NMR in biomedicine · 2025Article
- A comparison of T1ρ with native T1 and T2 mapping for detecting edema in takotsubo cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Article
- Features of cardiovascular magnetic resonance native T1 mapping in maintenance hemodialysis patients and their related factors.Renal failure · 2024Article
- Analysis of myocardial T1, T2, and T2* values by age, sex, and cardiac segments in normal population: a prospective study.The international journal of cardiovascular imaging · 2024Article
- Evaluation of Right Ventricular Myocardial Properties Using Systolic Myocardial T1 Mapping.Cureus · 2024Article
- Misclassification of females and males in cardiovascular magnetic resonance parametric mapping: the importance of sex-specific normal ranges for diagnosis of health vs. disease.European heart journal. Cardiovascular Imaging · 2024Article
- Insights into the effects of Friedreich ataxia on the left ventricle using T1 mapping and late gadolinium enhancement.PloS one · 2024Article
- Reference ranges of myocardial T1 and T2 mapping in healthy Chinese adults: a multicenter 3T cardiovascular magnetic resonance study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Longitudinal Changes in the Myocardial T1 Relaxation Time, Extracellular Volume Fraction, and Left Ventricular Function in Asymptomatic Men.Journal of cardiovascular development and disease · 2023Article
- Review
- Incident Clinical and Mortality Associations of Myocardial Native T1 in the UK Biobank.JACC. Cardiovascular imaging · 2023Article
- Reference values of myocardial native T1 and extracellular volume in patients without structural heart disease and had negative 3T cardiac magnetic resonance adenosine stress test.International journal of cardiology. Heart & vasculature · 2023Article
- Repeatability and reproducibility of cardiac manganese-enhanced magnetic resonance imaging.Scientific reports · 2023Article
- Reference values of myocardial native T1 and T2 mapping values in normal Indian population at 1.5 Tesla scanner.The international journal of cardiovascular imaging · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo use magnetic resonance imaging (MRI) at two field strengths to assess healthy adults' regional myocardial noncontrast (native) T1 relaxation time distribution, and global myocardial native T1 between sexes and across age groups. MATERIALS AND
methodsIn all, 84 healthy volunteers underwent MRI at 1.5T and 3.0T. T1 maps were acquired in three left ventricular short axis slices using an optimized modified Look-Locker inversion recovery investigational prototype sequence. T1 measurements in msec were calculated from 16 regions-of-interest, and a global T1 value from all evaluable segments per subject. Associations were assessed with a multivariate linear regression model.
resultsIn total, 1297 (96.5%) segments were evaluable at 1.5T and 1263 (94.0%) segments at 3.0T. Native T1 was higher in septal than lateral myocardium (1.5T: 956.3 ± 44.4 vs. 939.2 ± 54.2 msec; P < 0.001; 3.0T: 1158.2 ± 45.9 vs. 1148.9 ± 56.9 msec; P = 0.012). Native T1 decreased with increasing age in females but not in males. Among lowest age tertile (<33 years) global native T1 was higher in females than in males at 1.5T (960.0 ± 20.3 vs. 931.5 ± 22.2 msec, respectively; P = 0.003) and 3.0T (1166.5 ± 19.7 vs. 1130.2 ± 20.6 msec; P < 0.001). No sex differences were observed in upper age tertile (≥55 years) at 1.5T (937.7 ± 25.4 vs. 934.7 ± 22.3 msec; P = 0.762) or 3.0T (1153.0 ± 30.0 vs. 1132.3 ± 23.5 msec; P = 0.056). Association of global native T1 to age (P = 0.002) and sex (P < 0.001) was independent of field strength and body size.
conclusionIn healthy adults, native T1 values are highest in the ventricular septum. Global native T1 was inversely associated with age in women, but not in men. J. Magn. Reson. Imaging 2016;44:541-548.
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