ReviewNutrition reviews2016
Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism.
Review in Nutrition reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Can a diet rich in Brassicaceae help controlFrontiers in medicine · 2024Pooled it
- Systematic Review on the Metabolic Interest of Glucosinolates and Their Bioactive Derivatives for Human Health.Nutrients · 2023Pooled it
- Trial
- Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Trial
- Replacing soybean meal with fermented rapeseed meal improves growth performance and intramuscular fat deposition in growing-finishing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- From Glucosinolate Content to Isothiocyanate Yield: RethinkingNutrients · 2026Review
- The role of nutrition on thyroid health and disease: myths and facts.Journal of endocrinological investigation · 2026Review
- Dyslipidemias associated with endocrine disorders: a position statement of the working group of the nutrition hormones and metabolism club of the italian society of endocrinology (SIE).Journal of endocrinological investigation · 2026Review
- Influence of Heat Treatment Prior to Fortification on Goitrogenic Compounds, Iodine Stability and Antioxidant Activity in Cauliflower.Foods (Basel, Switzerland) · 2026Article
- Impact of Ayurvedic purification (Shodhana) onFrontiers in medicine · 2026Article
- Plant-derived nutritional components in thyroid disease-related neuropsychiatric disorders: mechanistic insights and advances.Frontiers in nutrition · 2026Review
- A comprehensive multi-evidence framework for network pharmacology-based prediction of dietary flavonoid effects.Frontiers in nutrition · 2026Article
- Application of Microorganisms for the Valorization of Side-Products of Rapeseed De-Oiling.Biomolecules · 2025Review
- Valorization of agri-food crucifer vegetables waste for food, functional food and nutraceuticals applications.Bioresources and bioprocessing · 2025Review
- Risk of hypothyroidism in meat-eaters, fish-eaters, and vegetarians: a population-based prospective study.BMC medicine · 2025Article
- Brassicaceae Isothiocyanate-Mediated Alleviation of Soil-Borne Diseases.Plants (Basel, Switzerland) · 2025Review
- Growth conditions trigger genotype-specific metabolic responses that affect the nutritional quality of kale cultivars.Journal of experimental botany · 2025Article
- Article
- The Effect of the Glucosinolate Sinigrin on Alterations in Molecular Biomarkers of the Myocardium in Swiss Mice.Foods (Basel, Switzerland) · 2025Article
- Supplemental effects of acidifier and encapsulated butyrate solely and combined in high canola meal diets for nursery pigs.Journal of animal science · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Brassica vegetables are common components of the diet and have beneficial as well as potentially adverse health effects. Following enzymatic breakdown, some glucosinolates in brassica vegetables produce sulforaphane, phenethyl, and indolylic isothiocyanates that possess anticarcinogenic activity. In contrast, progoitrin and indolylic glucosinolates degrade to goitrin and thiocyanate, respectively, and may decrease thyroid hormone production. Radioiodine uptake to the thyroid is inhibited by 194 μmol of goitrin, but not by 77 μmol of goitrin. Collards, Brussels sprouts, and some Russian kale (Brassica napus) contain sufficient goitrin to potentially decrease iodine uptake by the thyroid. However, turnip tops, commercial broccoli, broccoli rabe, and kale belonging to Brassica oleracae contain less than 10 μmol of goitrin per 100-g serving and can be considered of minimal risk. Using sulforaphane plasma levels following glucoraphanin ingestion as a surrogate for thiocyanate plasma concentrations after indole glucosinolate ingestion, the maximum thiocyanate contribution from indole glucosinolate degradation is estimated to be 10 μM, which is significantly lower than background plasma thiocyanate concentrations (40-69 μM). Thiocyanate generated from consumption of indole glucosinolate can be assumed to have minimal adverse risks for thyroid health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.