SynthesisMedicina oral, patologia oral y cirugia bucal2016
Efficacy of amoxicillin and amoxicillin/clavulanic acid in the prevention of infection and dry socket after third molar extraction. A systematic review and meta-analysis.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial
Does a Single Dose of Systemic Antibiotics Prevent Postoperative Inflammatory Complications After Lower Third Molar Surgery? A Randomized Controlled Trial
Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Antibiotics to prevent complications following tooth extractions.The Cochrane database of systematic reviews · 2021Pooled it
- A systematic review of latest evidence for antibiotic prophylaxis and therapy in oral and maxillofacial surgery.Infection · 2019Pooled it
- Comparison of the effects of antibiotic therapy and photobiomodulation with red and infrared lasers on the healing of postextraction sockets of third molars: A randomised controlled trial.Lasers in medical science · 2025Trial
- Piezosurgery versus conventional rotary surgery for impacted third molars: A randomised, split-mouth, clinical pilot trial.Medicina oral, patologia oral y cirugia bucal · 2024Trial
- Comparative Efficacy of Different Oral Doses of Clindamycin in Preventing Post-Operative Sequelae of Lower Third Molar Surgery-A Randomized, Triple-Blind Study.Medicina (Kaunas, Lithuania) · 2022Trial
- Piezo-surgery technique and intramuscular dexamethasone injection to reduce postoperative pain after impacted mandibular third molar surgery: a randomized clinical trial.BMC oral health · 2021Trial
- Postoperative effects of intra-alveolar application of 0.2% chlorhexidine or 1% hyaluronic acid bioadhesive gels after mandibular third molar extraction: a double-blind randomized controlled clinical trial.Clinical oral investigations · 2021Trial
- Randomized controlled trial on the effectiveness of absorbable collagen sponge after extraction of impacted mandibular third molar: split-mouth design.BMC oral health · 2020Trial
- Influence of Amoxicillin Dosage and Time of Administration on Postoperative Complications After Impacted Third Molar Surgery: A Randomized, Double-Blind, Controlled Clinical Trial.Antibiotics (Basel, Switzerland) · 2025Article
- Rational utilization of antibiotic prophylaxis in oral and maxillofacial surgery: a large scope review of recent data.BMC oral health · 2025Review
- Comparative Efficacy of Two Hemostatic Agents in Post-Extraction Bleeding Control Following Mandibular Third Molar Surgery: A Randomized Clinical Trial.Journal of functional biomaterials · 2025Article
- Antibiotics in Mucogingival Surgery for Recession Treatment: A Narrative Review.Antibiotics (Basel, Switzerland) · 2025Review
- Antibiotic Prescription for the Prevention of Postoperative Complications After Third-Molar Extractions: A Systematic Review.Dentistry journal · 2025Review
- Effect of Antibiotics on Clinical and Laboratory Outcomes After Mandibular Third Molar Surgery: A Double-Blind Randomized Clinical Trial.Antibiotics (Basel, Switzerland) · 2025Article
- Metronidazole for the Prophylaxis of Alveolar Osteitis: A Systematic Review and Meta-analysis.Journal of maxillofacial and oral surgery · 2025Review
- Prophylactic therapy for prevention of surgical site infection after extraction of third molar: An overview of reviews.Medicina oral, patologia oral y cirugia bucal · 2023Review
- Antibiotics in Dentistry: A Narrative Review of the Evidence beyond the Myth.International journal of environmental research and public health · 2023Review
- Antimicrobial Prophylaxis in Dentistry: Survey among Dental Surgeons in Porto Alegre, Brazil, and the Metropolitan Region.The American journal of tropical medicine and hygiene · 2023Article
- Antibiotics Efficiency in the Infection Complications Prevention after Third Molar Extraction: A Systematic Review.Dentistry journal · 2022Review
- Factors Influencing the Onset of Intra- and Post- Operative Complications Following Tooth Exodontia: Retrospective Survey on 1701 Patients.Antibiotics (Basel, Switzerland) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProphylactic use of amoxicillin and amoxicillin/clavulanic acid, although controversial, is common in routine clinical practice in third molar surgery. MATERIAL AND
methodsOur objective was to assess the efficacy of prophylactic amoxicillin with or without clavulanic acid in reducing the incidence of dry socket and/or infection after third molar extraction. We conducted a systematic review and meta-analysis consulting electronic databases and references in retrieved articles. We included double-blind placebo-controlled randomized clinical trials published up to June 2015 investigating the efficacy of amoxicillin with or without clavulanic acid on the incidence of the aforementioned conditions after third molar extraction. Relative risks (RRs) were estimated with a generic inverse-variance approach and a random effect model using Stata/IC 13 and Review Manager Version 5.2. Stratified analysis was performed by antibiotic type.
resultsWe included 10 papers in the qualitative review and in the quantitative synthesis (1997 extractions: 1072 in experimental groups and 925 in controls, with 27 and 74 events of dry socket and/or infection, respectively). The overall RR was 0.350 (p<0.001; 95% CI 0.214 to 0.574). We found no evidence of heterogeneity (I2=0%, p=0.470). The number needed to treat was 18 (95% CI 13 to 29). Five studies reported adverse reactions (RR=1.188, 95% CI 0.658 to 2.146, p =0.567). The RRs were 0.563 for amoxicillin (95% CI 0.295 to 1.08, p=0.082) and 0.215 for amoxicillin/clavulanic acid (95% CI 0.117 to 0.395, p<0.001).
conclusionsProphylactic use of amoxicillin does not significantly reduce the risk of infection and/or dry socket after third molar extraction. With amoxicillin/clavulanic acid, the risk decreases significantly. Nevertheless, considering the number needed to treat, low prevalence of infection, potential adverse reactions to antibiotics and lack of serious complications in placebo groups, the routine prescription of amoxicillin with or without clavulanic acid is not justified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.