Evidence map›Paper›PMID 26946055›Full record

ArticleAdvanced healthcare materials2016

Destruction of Opportunistic Pathogens via Polymer Nanoparticle-Mediated Release of Plant-Based Antimicrobial Payloads.

Dahlia N Amato, Douglas V Amato, Olga V Mavrodi, Dwaine A Braasch, Susan E Walley, Jessica R Douglas, Dmitri V Mavrodi, Derek L Patton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Antimicrobial Activity of, and Cellular Pathways Targeted by,Applied and environmental microbiology · 2020
    Article
  5. Frontiers in microbiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dahlia N AmatoSchool of Polymers and High Performance Materials, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Douglas V AmatoSchool of Polymers and High Performance Materials, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Olga V MavrodiDepartment of Biological Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Dwaine A BraaschSchool of Polymers and High Performance Materials, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Susan E WalleySchool of Polymers and High Performance Materials, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Jessica R DouglasSchool of Polymers and High Performance Materials, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Dmitri V MavrodiDepartment of Biological Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Derek L PattonSchool of Polymers and High Performance Materials, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
University of Southern Mississippi · US

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
TOUGALOO PROTEOMICSP20RR016476 · NCRR · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI SHEARER, GLEN · 2001 to 2011
$30.4M
NCRR NIH HHS P20 RR016476NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

The synthesis of antimicrobial thymol/carvacrol-loaded polythioether nanoparticles (NPs) via a one-pot, solvent-free miniemulsion thiol-ene photopolymerization process is reported. The active antimicrobial agents, thymol and carvacrol, are employed as "solvents" for the thiol-ene monomer phase in the miniemulsion to enable facile high capacity loading (≈50% w/w), excellent encapsulation efficiencies (>95%), and elimination of all postpolymerization purification processes. The NPs serve as high capacity reservoirs for slow-release and delivery of thymol/carvacrol-combination payloads that exhibit inhibitory and bactericidal activity (>99.9% kill efficiency at 24 h) against gram-positive and gram-negative bacteria, including both saprophytic (Bacillus subtilis ATCC 6633 and Escherichia coli ATCC 25922) and pathogenic species (E. coli ATCC 43895, Staphylococcus aureus RN6390, and Burkholderia cenocepacia K56-2). This report is among the first to demonstrate antimicrobial efficacy of essential oil-loaded nanoparticles against B. cenocepacia - an innately resistant opportunistic pathogen commonly associated with debilitating respiratory infections in cystic fibrosis. Although a model platform, these results point to promising pathways to particle-based delivery of plant-derived extracts for a range of antimicrobial applications, including active packaging materials, topical antiseptics, and innovative therapeutics.

Indexed as

Biodegradable PlasticsMonoterpenesNanoparticlesThymolBacteriaBacterial InfectionsCymenesDelayed-Action PreparationsOpportunistic InfectionsBiodegradable PlasticscarvacrolCymenesDelayed-Action PreparationsMonoterpenesThymolantimicrobialcarvacrolminiemulsion polymerizationpolymer nanoparticlesthymol

Identifiers

PMID26946055
PMCPMC5474087
OpenAlexW2289367852

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.