ArticleHeart and vessels2016
New insights into spotty calcification and plaque rupture in acute coronary syndrome: an optical coherence tomography study.
Article in Heart and vessels, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- High-risk plaque characteristics associated with recurrent stroke in patients with intracranial stenosis: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- Prognostic Role and Therapeutic Implications of Intravascular Optical Coherence Tomography Detected Coronary Plaque Microstructures in Patients with Coronary Artery Disease.Journal of clinical medicine · 2025Review
- AI-based modality-agnostic classification system for vascular calcifications.Scientific reports · 2025Article
- Atherosclerotic Diseases in Chronic Kidney Disease.Journal of atherosclerosis and thrombosis · 2025Review
- Using artificial intelligence to study atherosclerosis from computed tomography imaging: A state-of-the-art review of the current literature.Atherosclerosis · 2024Review
- A Review Paper on Optical Coherence Tomography Evaluation of Coronary Calcification Pattern: Is It Relevant Today?Journal of cardiovascular development and disease · 2024Review
- Coronary artery calcification and plaque stability： an optical coherence tomography study.Heliyon · 2023Article
- Changes in intra- and extracranial carotid plaque calcification: a 2-year follow-up study.Scientific reports · 2023Article
- Intracoronary Imaging of Coronary Atherosclerotic Plaque: From Assessment of Pathophysiological Mechanisms to Therapeutic Implication.International journal of molecular sciences · 2023Review
- SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Low bone mineral density and coronary artery disease: A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2021Review
- Carotid Artery Calcification: What We Know So Far.Cureus · 2021Review
- Uric Acid-to-Albumin Ratio: A Novel Marker for the Extent of Coronary Artery Disease in Patients with Non-ST-Elevated Myocardial Infarction.Pulse (Basel, Switzerland) · 2021Article
- Association of culprit lesion plaque characteristics with flow restoration post-fibrinolysis in ST-segment elevation myocardial infarction: an intravascular ultrasound-virtual histology study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2020Article
- Superficial Calcification With Rotund Shape Is Associated With Carotid Plaque Rupture: An Optical Coherence Tomography Study.Frontiers in neurology · 2020Article
- Calcification in Atherosclerotic Plaque Vulnerability: Friend or Foe?Frontiers in physiology · 2020Review
- Intrinsic calcification angle: a novel feature of the vulnerable coronary plaque in patients with type 2 diabetes: an optical coherence tomography study.Cardiovascular diabetology · 2019Observational
- A novel fluorescein-bisphosphonate based diagnostic tool for the detection of hydroxyapatite in both cell and tissue models.Scientific reports · 2018Article
- Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Baseline Serum Uric Acid Levels Are Associated with All-Cause Mortality in Acute Coronary Syndrome Patients after Percutaneous Coronary Intervention.Disease markers · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although recent optical coherence tomography (OCT) studies have focused on spotty calcification, whether there were any characteristics in the concomitant existence of calcification and plaque rupture remains unknown. The aim of the present study was to investigate the characteristics of spotty calcification in acute coronary syndrome (ACS) patients with or without plaque rupture, using OCT. This study enrolled 98 consecutive patients with ACS. OCT image acquisitions were performed in the culprit lesions, and patients were divided into the plaque rupture group (n = 38) and the non-rupture group (n = 60). The frequency of spotty calcification (p = 0.006), thin-capped fibroatheroma (p = 0.012), macrophage infiltration (p = 0.022), and the number of spotty calcification per patient (p < 0.001) were significantly higher and the largest arc and the minimum depth of spotty calcification from the luminal surface were significantly smaller in the rupture group. Moreover, in the rupture group, most of the spotty calcifications in the site nearest to the minimum lumen area were observed in the proximal portion of that site, and tended to be located near the plaque rupture. Multivariate analysis revealed that the presence of spotty calcification (OR 3.19, 95 % CI 1.12-9.76, p = 0.030) and age (OR 1.08, 95 % CI 1.02-1.14, p = 0.008) were independent predictive factors for plaque rupture. This study demonstrates the characteristics of spotty calcification in ACS patients with plaque rupture and the positional relationship between spotty calcification and plaque rupture. These detailed observations could impact on treatment strategies for the prevention of ACS.
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