ReviewAnnals of the New York Academy of Sciences2016
Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations.
Review in Annals of the New York Academy of Sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Hyperbaric oxygen therapy for ischemic encephalopathy following occupational exposure to high-concentration toxic gases: two Case Reports.Frontiers in toxicology · 2026Article
- The NADPH oxidase inhibitor diphenyleneiodonium suppresses CaThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024Article
- A case of syncope in a villager with hypertrophic cardiomyopathy after hydrogen sulfide exposure by an unauthorized discharge of wastewater.Annals of occupational and environmental medicine · 2023Article
- Case report: Analysis of a case of hydrogen sulfide poisoning in a waste treatment plant.Frontiers in public health · 2023Article
- Analysis of CT and MR imaging features of the brain in patients with hydrogen sulfide poisoning based on clinical symptom grading.BMC neurology · 2022Article
- S-Nitroso-l-cysteine and ventilatory drive: A pediatric perspective.Pediatric pulmonology · 2022Review
- Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.Oxidative medicine and cellular longevity · 2022Article
- Effect of gaseous hydrogen sulphide on growth performance and cecal microbial diversity of weaning pigs.Veterinary medicine and science · 2021Article
- Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease.Journal of inherited metabolic disease · 2020Article
- Azure B as a novel cyanide antidote: Preclinical in-vivo studies.Toxicology reports · 2020Article
- Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2019Review
- Methylene Blue Administration During and After Life-Threatening Intoxication by Hydrogen Sulfide: Efficacy Studies in Adult Sheep and Mechanisms of Action.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- On the Efficacy of Cardio-Pulmonary Resuscitation and Epinephrine Following Cyanide- and HCardiovascular toxicology · 2018Article
- Methylene Blue Counteracts HCardiovascular toxicology · 2018Article
- Clinical chameleons: an emergency medicine focused review of carbon monoxide poisoning.Internal and emergency medicine · 2018Review
- The Use of Biomass for Electricity Generation: A Scoping Review of Health Effects on Humans in Residential and Occupational Settings.International journal of environmental research and public health · 2018Article
- Analysis of decreases in systemic arterial pressure and heart rate in response to the hydrogen sulfide donor sodium sulfide.American journal of physiology. Heart and circulatory physiology · 2017Article
- H2S concentrations in the heart after acute H2S administration: methodological and physiological considerations.American journal of physiology. Heart and circulatory physiology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Hydrogen sulfide (H2 S) is a chemical hazard in the gas and farming industry. As it is easy to manufacture from common chemicals, it has also become a method of suicide. H2 S exerts its toxicity through its high affinity with metalloproteins, such as cytochrome c oxidase and possibly via its interactions with cysteine residues of various proteins. The latter was recently proposed to acutely alter ion channels with critical implications for cardiac and brain functions. Indeed, during severe H2 S intoxication, a coma, associated with a reduction in cardiac contractility, develops within minutes or even seconds leading to death by complete electromechanical dissociation of the heart. In addition, long-term neurological deficits can develop owing to the direct toxicity of H2 S on neurons combined with the consequences of a prolonged apnea and circulatory failure. Here, we review the challenges impeding efforts to offer an effective treatment against H2 S intoxication using agents that trap free H2 S, and present novel pharmacological approaches aimed at correcting some of the most harmful consequences of H2 S intoxication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.