ArticleMedicine2016
Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What Are the Normal Serum Creatine Kinase Values for Skeletal Muscle? A Worldwide Systematic Review.European journal of neurology · 2025Pooled it
- A Nationwide Nepalese Study to Establish Reference Intervals for Major Biochemical Analytes with Elucidation of Nepalese Features of Reference Values.Indian journal of clinical biochemistry : IJCB · 2024Article
- Circulating ceramide levels and ratios in Emirati youth under 18 years: associations with cardiometabolic risk factors.Lipids in health and disease · 2024Article
- Derivation of Russian-specific reference intervals for complete blood count, iron markers and related vitamins.PloS one · 2024Article
- Establishment of dry-chemistry-based reference intervals of routine liver function tests for the adult population of Gandaki Province, Nepal.PLOS global public health · 2024Article
- Establishment of Reference Intervals for Renal Function Clinical Chemistry Parameters in an Indonesian Tertiary Hospital.Archives of Razi Institute · 2023Article
- Establishment and validation of reference intervals for tumor markers (AFP, CEA, CA19-9, CA15-3, CA125, PSA, HE4, Cyfra 21-1, and ProGRP) in primary care centers in Korea: A cross-sectional retrospective study.Health science reports · 2023Article
- New comprehensive reference values for kidney function indexes across adult and geriatric ages in Chinese popuplation.Heliyon · 2022Article
- Establishment of gender- and age-specific reference intervals for serum liver function tests among the elderly population in northeast China: a retrospective study.Biochemia medica · 2022Article
- Establishment of dry chemistry based reference intervals of renal function test parameters for the adult population of Kaski District, Nepal.BMC nephrology · 2021Article
- Reference intervals for 26 common biochemical analytes in term neonates in Jilin Province, China.BMC pediatrics · 2021Article
- Establishment of reference intervals of clinical chemistry analytes for the adult population in Egypt.PloS one · 2021Article
- Reference intervals of common clinical biochemistry analytes in young Nigerian adults.PloS one · 2021Article
- Gender and age-specific reference intervals of common biochemical analytes in Chinese population: Derivation using real laboratory data.Journal of medical biochemistry · 2020Article
- Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials.European journal of clinical pharmacology · 2020Article
- The Imperative of Population-Specific Biochemical Reference Intervals: A Translational Framework for Precision Public Health.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
- Variation in normative values of major clinical biochemistry analytes in healthy reproductive-age women in India: A subset of data from a National Indian Council of Medical Research-Polycystic Ovary Syndrome task force study.Indian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A nationwide multicenter study was conducted in the China to explore sources of variation of reference values and establish reference intervals for 28 common biochemical analytes, as a part of the International Federation of Clinical Chemistry and Laboratory Medicine, Committee on Reference Intervals and Decision Limits (IFCC/C-RIDL) global study on reference values. A total of 3148 apparently healthy volunteers were recruited in 6 cities covering a wide area in China. Blood samples were tested in 2 central laboratories using Beckman Coulter AU5800 chemistry analyzers. Certified reference materials and value-assigned serum panel were used for standardization of test results. Multiple regression analysis was performed to explore sources of variation. Need for partition of reference intervals was evaluated based on 3-level nested ANOVA. After secondary exclusion using the latent abnormal values exclusion method, reference intervals were derived by a parametric method using the modified Box-Cox formula. Test results of 20 analytes were made traceable to reference measurement procedures. By the ANOVA, significant sex-related and age-related differences were observed in 12 and 12 analytes, respectively. A small regional difference was observed in the results for albumin, glucose, and sodium. Multiple regression analysis revealed BMI-related changes in results of 9 analytes for man and 6 for woman. Reference intervals of 28 analytes were computed with 17 analytes partitioned by sex and/or age. In conclusion, reference intervals of 28 common chemistry analytes applicable to Chinese Han population were established by use of the latest methodology. Reference intervals of 20 analytes traceable to reference measurement procedures can be used as common reference intervals, whereas others can be used as the assay system-specific reference intervals in China.
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