ReviewFertility and sterility2016
Local and systemic factors and implantation: what is the evidence?
Review in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04107129 (Predicting Endometrial Receptivity for Optimal Reproductive Management), which is not on this map. Cited by 72 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predicting Endometrial Receptivity for Optimal Reproductive Management (PERFORM)
Who cites it
72 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Interventions for recurrent embryo implantation failure: An umbrella review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Pooled it
- The value of G-CSF in women experienced at least one implantation failure: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes.The Cochrane database of systematic reviews · 2020Pooled it
- Four-dimensional ultrasound guided embryo transfers improve live birth rates when compared to the clinical touch technique: a randomised controlled trial.Scientific reports · 2023Trial
- Immunological Role of Intrauterine Human Chorionic Gonadotropin in Infertile Women Undergoing ICSI.Journal of obstetrics and gynaecology of India · 2026Article
- Aberrant progesterone receptor (PGR) expression is associated with estrogen receptor 1 (ESR1) expression in the endometrium from infertile women with endometriosis.Molecular human reproduction · 2026Article
- Reproductive outcomes after expectant management and 5- versus 15-minute laparoscopic ethanol sclerotherapy for ovarian endometriomas: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Resolved hyperthyroidism before IVF is not associated with improved cumulative live birth rates: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Endometrial immune cell profile at the time of frozen embryo transfer as prognostic indicator of live birth.Frontiers in immunology · 2026Observational
- Optimal management of large endometriomas (≥ 4 cm) before IVF: ethanol sclerotherapy, cystectomy, or no intervention?BMC women's health · 2025Article
- Review
- Prospective evaluation of mid-luteal endometrial BCL6/SIRT and correlation with outcomes of euploid frozen embryo transfer: a prospective cohort study.Journal of assisted reproduction and genetics · 2025Observational
- GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization.Nature communications · 2025Article
- Ethanol Sclerotherapy for Endometriomas in Infertile Women: A Narrative Review.Journal of clinical medicine · 2024Review
- The impact of estradiol supplementation on endometrial thickness and intrauterine insemination outcomes.Reproductive biology · 2024Article
- Transcriptomic changes in eutopic endometrium and ectopic lesions during endometriosis progression in a mouse model.F&S science · 2024Article
- The reproductive potential of vitrified-warmed euploid embryos declines following repeated uterine transfers.Reproductive biology and endocrinology : RB&E · 2024Observational
- Perspective Exploring Novel Associations of IL-18 Levels as a Mediator of the Causal Links between Major Depression and Reproductive Health.Depression and anxiety · 2024Article
- Association of recurrent implantation failure and recurrent pregnancy loss with peripheral blood natural killer cells and interferon-gamma level.Obstetrics & gynecology science · 2024Article
- The use of propensity score matching to assess the effectiveness of the endometrial receptivity analysis in patients with recurrent implantation failure.Frontiers in endocrinology · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Significant progress has been made in the understanding of embryonic competence and endometrial receptivity since the inception of assisted reproductive technology. The endometrium is a highly dynamic tissue that plays a crucial role in the establishment and maintenance of normal pregnancy. In response to steroid sex hormones, the endometrium undergoes marked changes during the menstrual cycle that are critical for acceptance of the nascent embryo. There is also a wide body of literature on systemic factors that impact assisted reproductive technology outcomes. Patient prognosis is impacted by an array of factors that tip the scales in her favor or against success. Recognizing the local and systemic factors will allow clinicians to better understand and optimize the maternal environment at the time of implantation. This review will address the current literature on endometrial and systemic factors related to impaired implantation and highlight recent advances in this area of reproductive medicine.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.