ArticleNeuropsychologia2016
Cognitive and anatomic double dissociation in the representation of concrete and abstract words in semantic variant and behavioral variant frontotemporal degeneration.
Article in Neuropsychologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- An ALE meta-analytical review of the neural correlates of abstract and concrete words.Scientific reports · 2021Pooled it
- Development, Normative Data, and Psychometric Properties of the Turkish Semantic Association Test (SEMAT) for Middle-Aged and Older Adults.Brain and behavior · 2026Article
- Emotional and Social Dimension of Abstract Concepts Meet with Interoception in Right Anterior Insula.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Automatic classification of AD pathology in FTD phenotypes using natural speech.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration.Neurology · 2024Article
- Network anatomy in logopenic variant of primary progressive aphasia.Human brain mapping · 2023Article
- Concrete and Abstract Concepts in Primary Progressive Aphasia and Alzheimer's Disease: A Scoping Review.Brain sciences · 2023Article
- Distinguishing Semantic Variant Primary Progressive Aphasia from Alzheimer's Disease.Journal of Alzheimer's disease reports · 2023Article
- Orienting to different dimensions of word meaning alters the representation of word meaning in early processing regions.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022Article
- Social and emotion dimensional organizations in the abstract semantic space: the neuropsychological evidence.Scientific reports · 2021Article
- Automated analysis of lexical features in frontotemporal degeneration.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology.Acta neuropathologica communications · 2021Article
- Cross-sectional and longitudinal medial temporal lobe subregional atrophy patterns in semantic variant primary progressive aphasia.Neurobiology of aging · 2021Article
- Automated analysis of lexical features in Frontotemporal Degeneration.medRxiv : the preprint server for health sciences · 2020Article
- Clinical Features of Late-onset Semantic Dementia.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2020Article
- Fleeting Perceptual Experience and the Possibility of Recalling Without Seeing.Scientific reports · 2020Article
- So Many Are "Few," but so Few Are Also "Few" - Reduced Semantic Flexibility in bvFTD Patients.Frontiers in psychology · 2020Article
- Dissociating action and abstract verb comprehension post-stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We examine the anatomic basis for abstract and concrete lexical representations in semantic memory by assessing patients with focal neurodegenerative disease. Prior evidence from healthy adult studies suggests that there may be an anatomical dissociation between abstract and concrete representations: abstract words more strongly activate the left inferior frontal gyrus relative to concrete words, while concrete words more strongly activate left anterior-inferior temporal regions. However, this double dissociation has not been directly examined. We test this dissociation in two patient groups with focal cortical atrophy in each of these regions, the behavioral variant of Frontotemporal Degeneration (bvFTD) and the semantic variant of Primary Progressive Aphasia (svPPA). We administered an associativity judgment task for abstract and concrete words, where subjects select which of two words is best associated with a given target word. Both bvFTD and svPPA patients were significantly impaired in their overall performance compared to controls. While controls treated concrete and abstract words equally, we found a category-specific double dissociation in patients' judgments: bvFTD patients showed a concreteness effect (CE), with significantly worse performance for abstract compared to concrete words, while svPPA patients showed reversal of the CE, with significantly worse performance for concrete over abstract words. Regression analyses also revealed an anatomic double dissociation: The CE is associated with inferior frontal atrophy in bvFTD, while reversal of the CE is associated with left anterior-inferior temporal atrophy in svPPA. These results support a cognitive and anatomic model of semantic memory organization where abstract and concrete representations are supported by dissociable neuroanatomic substrates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.