ArticleApplied and environmental microbiology2016
Global Genomic Epidemiology of Salmonella enterica Serovar Typhimurium DT104.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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57 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Antimicrobial use regulations are associated with increased susceptibility among bovineOne health (Amsterdam, Netherlands) · 2025Article
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- Potential links between human bloodstream infection by Salmonella enterica serovar Typhimurium and international transmission to Colombia.PLoS neglected tropical diseases · 2025Article
- Genomic characterization of a clonal emergentApplied and environmental microbiology · 2024Article
- Comparative Gene Expression Analysis ofMicroorganisms · 2024Article
- Using SNP addresses forEpidemiology and infection · 2023Article
- A multidrug-resistantMicrobial genomics · 2023Article
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- Whole-genome sequencing of multidrug resistanceFrontiers in public health · 2023Article
- Egg-associatedFrontiers in microbiology · 2023Article
- Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-AssociatedVeterinary sciences · 2022Review
- Capsaicin Potently BlocksAntibiotics (Basel, Switzerland) · 2022Article
- Whole-Genome Analysis of Multidrug-ResistantPathogens (Basel, Switzerland) · 2021Article
- Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.Microbiology spectrum · 2021Article
- Recent Evolution and Genomic Profile of Salmonella enterica Serovar Heidelberg Isolates from Poultry Flocks in Brazil.Applied and environmental microbiology · 2021Article
- Cellular Activity ofToxins · 2021Article
- Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia.Nature communications · 2021Article
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11 authors.
Funding
Abstract
It has been 30 years since the initial emergence and subsequent rapid global spread of multidrug-resistant Salmonella entericaserovar Typhimurium DT104 (MDR DT104). Nonetheless, its origin and transmission route have never been revealed. We used whole-genome sequencing (WGS) and temporally structured sequence analysis within a Bayesian framework to reconstruct temporal and spatial phylogenetic trees and estimate the rates of mutation and divergence times of 315S Typhimurium DT104 isolates sampled from 1969 to 2012 from 21 countries on six continents. DT104 was estimated to have emerged initially as antimicrobial susceptible in ∼1948 (95% credible interval [CI], 1934 to 1962) and later became MDR DT104 in ∼1972 (95% CI, 1972 to 1988) through horizontal transfer of the 13-kb Salmonella genomic island 1 (SGI1) MDR region into susceptible strains already containing SGI1. This was followed by multiple transmission events, initially from central Europe and later between several European countries. An independent transmission to the United States and another to Japan occurred, and from there MDR DT104 was probably transmitted to Taiwan and Canada. An independent acquisition of resistance genes took place in Thailand in ∼1975 (95% CI, 1975 to 1990). In Denmark, WGS analysis provided evidence for transmission of the organism between herds of animals. Interestingly, the demographic history of Danish MDR DT104 provided evidence for the success of the program to eradicate Salmonellafrom pig herds in Denmark from 1996 to 2000. The results from this study refute several hypotheses on the evolution of DT104 and suggest that WGS may be useful in monitoring emerging clones and devising strategies for prevention of Salmonella infections.
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