Evidence map›Paper›PMID 26944674›Full record

ArticleGenes & development2016

Making choices-how stochastic decisions determine disease progression.

Ki-Sun Park, Karl Pfeifer

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ki-Sun ParkEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20814, USA.
Karl PfeiferEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20814, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · US

Funding

Regulated expression and developmental functions of the H19 long noncoding RNAZIAHD001804 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PFEIFER, KARL ERIC · 2009 to 2025
$20.2M
Intramural NIH HHS
6 · The paper itself

Abstract

In this issue of Genes & Development, Ginart and colleagues (pp. 567-578) study a mouse model for Russell-Silver syndrome (RSS) and show that similar cells within one individual can display distinct gene expression patterns because of epigenetic marks that are established stochastically during early development. Their results provide an excellent explanation for phenotypes seen in RSS and other imprinting disorders and especially help us understand how patients with similar or even identical genetic mutations can display distinct disease profiles.

Indexed as

Disease ProgressionGene Expression Regulation, DevelopmentalAllelesAnimalsDNA MethylationGene DosageGenomic ImprintingHumansMiceModels, AnimalMutationgene expressionimprintingsingle cell

Identifiers

PMID26944674
PMCPMC4782042
OpenAlexW2290239231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.