Evidence map›Paper›PMID 26944605›Full record

ArticleNeuroscience2016

Repetitive acute intermittent hypoxia increases growth/neurotrophic factor expression in non-respiratory motor neurons.

I Satriotomo, N L Nichols, E A Dale, A T Emery, J M Dahlberg, G S Mitchell

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03071393 (Acute Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03071393 nacompletednot on this mapstarted 2017, after this paper: background citation

Acute Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury

TypeinterventionalSponsorUniversity of FloridaRan2017 to 2020Enrolled17ConditionsSpinal Cord InjuriesArmsHypoxia via Hypoxico Hyp-123, Sham via Hypoxico Hyp-123
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

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  15. Dose-dependent phosphorylation of endogenous Tau by intermittent hypoxia in rat brain.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

I SatriotomoDepartment of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA. Electronic address: satriotomo@ufl.edu.
N L NicholsDepartment of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA.
E A DaleDepartment of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA.
A T EmeryDepartment of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA.
J M DahlbergDepartment of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA.
G S MitchellDepartment of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA.
University of Wisconsin–Madison · US

Funding

Respiratory plasticity and spinal cord InjuryR37HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2002 to 2011
$4.2M
Mechanisms of respiratory long-term facilitationR01HL080209 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2005 to 2013
$2.9M
Respiratory Plasticity and Spinal Cord InjuryR01HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2014 to 2017
$1.5M
Enhanced respiratory plasticity in models of respiratory motor neuron deathR00HL119606 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI NICHOLS, NICOLE L. · 2015 to 2017
$724k
Enhanced respiratory plasticity in models of respiratory motor neuron deathK99HL119606 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI NICHOLS, NICOLE L. · 2014 to 2014
$104k
NHLBI NIH HHS HL080209NHLBI NIH HHS HL69064NHLBI NIH HHS K99 HL119606NHLBI NIH HHS R00 HL119606NHLBI NIH HHS R01 HL069064NHLBI NIH HHS R01 HL080209NHLBI NIH HHS R37 HL069064
6 · The paper itself

Abstract

Repetitive acute intermittent hypoxia (rAIH) increases growth/trophic factor expression in respiratory motor neurons, thereby eliciting spinal respiratory motor plasticity and/or neuroprotection. Here we demonstrate that rAIH effects are not unique to respiratory motor neurons, but are also expressed in non-respiratory, spinal alpha motor neurons and upper motor neurons of the motor cortex. In specific, we used immunohistochemistry and immunofluorescence to assess growth/trophic factor protein expression in spinal sections from rats exposed to AIH three times per week for 10weeks (3×wAIH). 3×wAIH increased brain-derived neurotrophic factor (BDNF), its high-affinity receptor, tropomyosin receptor kinase B (TrkB), and phosphorylated TrkB (pTrkB) immunoreactivity in putative alpha motor neurons of spinal cervical 7 (C7) and lumbar 3 (L3) segments, as well as in upper motor neurons of the primary motor cortex (M1). 3×wAIH also increased immunoreactivity of vascular endothelial growth factor A (VEGFA), the high-affinity VEGFA receptor (VEGFR-2) and an important VEGF gene regulator, hypoxia-inducible factor-1α (HIF-1α). Thus, rAIH effects on growth/trophic factors are characteristic of non-respiratory as well as respiratory motor neurons. rAIH may be a useful tool in the treatment of disorders causing paralysis, such as spinal injury and motor neuron disease, as a pretreatment to enhance motor neuron survival during disease, or as preconditioning for cell-transplant therapies.

Indexed as

AnimalsBrain-Derived Neurotrophic FactorCervical VertebraeHypoxiaHypoxia-Inducible Factor 1, alpha SubunitImmunohistochemistryLumbar VertebraeMaleMotor CortexMotor NeuronsPhosphorylationRandom AllocationRats, Sprague-DawleyReceptor, trkBSpinal CordVascular Endothelial Growth Factor ABrain-Derived Neurotrophic FactorHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitReceptor, trkBVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratBDNFHIF-1intermittent hypoxiamotor neuronTrkBVEGF

Identifiers

PMID26944605
PMCPMC5203934
OpenAlexW2290591927

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.