ArticleBMC genomics2016
Integrating transcriptomics and metabolomics to characterise the response of Astragalus membranaceus Bge. var. mongolicus (Bge.) to progressive drought stress.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 100 citations in OpenAlex.
- Article
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- Metabolomics combined with transcriptomics and physiology reveals the regulatory responses of soybean plants to drought stress.Frontiers in genetics · 2024Article
- Integrated transcriptomic, proteomic and metabolomic analyses revealing the roles of amino acid and sucrose metabolism in augmenting drought tolerance inFrontiers in plant science · 2024Article
- Comparative transcriptome analysis of Saposhnikovia divaricata to reveal drought and rehydration adaption strategies.Molecular biology reports · 2023Article
- Metabolomic Analysis Reveals the Metabolic Diversity of Wild and Cultivated Stellaria Radix (Plants (Basel, Switzerland) · 2023Article
- A Protective Role of Phenylalanine Ammonia-Lyase fromInternational journal of molecular sciences · 2022Article
- Metabolic accumulation and related synthetic genes of O-acetyl groups in mannan polysaccharides of Dendrobium officinale.Protoplasma · 2022Article
- Combined analysis of transcriptome and metabolome reveals the molecular mechanism and candidate genes ofFrontiers in plant science · 2022Article
- Transcriptome and Metabolome Analyses Reveal Molecular Responses of Two Pepper (Frontiers in plant science · 2022Article
- Comparative Ionomics and Metabolic Responses and Adaptive Strategies of Cotton to Salt and Alkali Stress.Frontiers in plant science · 2022Article
- l-Aspartate: An Essential Metabolite for Plant Growth and Stress Acclimation.Molecules (Basel, Switzerland) · 2021Review
- Metabolite Analysis of Jerusalem Artichoke (International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAstragalus membranaceus Bge. var. mongolicus (Bge.) Hsiao (A. mongolicus) is an important traditional Chinese herb that is cultivated on a large scale in northwestern China. Understanding plant responses to drought has important effects on ecological environment recovery and local economic development. Here, we combined transcriptomics (Illumina Hiseq 2000) and metabolomics ((1)H-NMR) to investigate how the roots of two-year-old A. mongolicus responded to 14 days of progressive drought stress.
resultsThe dried soil reduced the relative water content (RWC) of the leaves and biomass, induced the differential expression of a large fraction of the transcriptome and significantly altered the metabolic processes. PCA analysis demonstrated that the sucrose, proline, and malate metabolites contributed greatly to the separation. Strikingly, proline was increased by almost 60-fold under severe stress compared to the control. Some backbone pathways, including glycolysis, tricarboxylic acid (TCA) cycle, glutamate-mediated proline biosynthesis, aspartate family metabolism and starch and sucrose metabolism, were significantly affected by drought. An integrated analysis of the interaction between key genes and the altered metabolites involved in these pathways was performed.
conclusionsOur findings demonstrated that the expression of drought-responsive genes showed a strong stress-dose dependency. Analysis of backbone pathways of the transcriptome and metabolome revealed specific genotypic responses to different levels of drought. The variation in molecular strategies to the drought may play an important role in how A. mongolicus and other legume crops adapt to drought stress.
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