ReviewLearning & behavior2016
Still searching for the engram.
Review in Learning & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Behavioral timescale synaptic plasticity: properties, elements and functions.Nature neuroscience · 2026Review
- Formation of an expanding memory representation in the hippocampus.Nature neuroscience · 2025Article
- Motivating Effects of Negative-hedonic Valence Encoded in Engrams.Research square · 2025Article
- Time-domain brain: temporal mechanisms for brain functions using time-delay nets, holographic processes, radio communications, and emergent oscillatory sequences.Frontiers in computational neuroscience · 2025Article
- Memory engram stability and flexibility.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Memory Storage in Distributed Engram Cell Ensembles.Advances in neurobiology · 2024Review
- If Engrams Are the Answer, What Is the Question?Advances in neurobiology · 2024Article
- Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Opto-extinction of a threat memory in mice.Brain research bulletin · 2022Article
- Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP.Neuropharmacology · 2022Article
- Correcting the hebbian mistake: Toward a fully error-driven hippocampus.PLoS computational biology · 2022Article
- Article
- Heksor: the central nervous system substrate of an adaptive behaviour.The Journal of physiology · 2022Article
- Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions.Nature communications · 2022Article
- Time Is of the Essence: Neural Codes, Synchronies, Oscillations, Architectures.Frontiers in computational neuroscience · 2022Article
- Miniature microscopes for manipulating and recording in vivo brain activity.Microscopy (Oxford, England) · 2021Article
- Fear conditioning potentiates the hippocampal CA1 commissural pathway in vivo and increases awake phase sleep.Hippocampus · 2021Article
- The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating.Neurobiology of learning and memory · 2020Review
- Neuronal Activity at Synapse Resolution: Reporters and Effectors for Synaptic Neuroscience.Frontiers in molecular neuroscience · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
For nearly a century, neurobiologists have searched for the engram-the neural representation of a memory. Early studies showed that the engram is widely distributed both within and across brain areas and is supported by interactions among large networks of neurons. Subsequent research has identified engrams that support memory within dedicated functional systems for habit learning and emotional memory, but the engram for declarative memories has been elusive. Nevertheless, recent years have brought progress from molecular biological approaches that identify neurons and networks that are necessary and sufficient to support memory, and from recording approaches and population analyses that characterize the information coded by large neural networks. These new directions offer the promise of revealing the engrams for episodic and semantic memories.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.